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show all sequences of 2.3.3.5

Distribution of the methylcitric acid cycle and beta-oxidation pathway for propionate catabolism in fungi

Miyakoshi, S.; Uchiyama, H.; Someya, T.; Satoh, T.; Tabuchi, T.; Agric. Biol. Chem. 51, 2381-2387 (1987)
No PubMed abstract available

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
propanoyl-CoA + H2O + oxaloacetate
Neurospora crassa
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Aspergillus niger
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Ogataea angusta
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Lipomyces starkeyi
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Kluyveromyces marxianus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Cryptococcus neoformans
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Vanrija humicola
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Wickerhamiella pararugosa
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Rhizopus microsporus var. chinensis
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Mucor rouxianus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Ustilago utriculosa
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Ustilago crus-galli
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Wickerhamomyces anomalus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Metschnikowia pulcherrima
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Cutaneotrichosporon curvatus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Debaryomyces hansenii
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Cyberlindnera saturnus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Saccharomycopsis fibuligera
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Diutina catenulata
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Candida gropengiesseri
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Schwanniomyces polymorphus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Priceomyces haplophilus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Starmerella magnoliae
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Torulaspora delbrueckii
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Citeromyces matritensis
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Saccharomyces cerevisiae
first key enzyme of the methylcitric acid cycle
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Pseudomonas aeruginosa
first key enzyme of the methylcitric acid cycle
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Yarrowia lipolytica
first key enzyme of the methylcitric acid cycle
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Rhizopus microsporus var. chinensis IAM 6003
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Neurospora crassa IFO 6067
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Mucor rouxianus IFO 5773
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Saccharomyces cerevisiae SANK 50182
first key enzyme of the methylcitric acid cycle
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Ustilago utriculosa F-B-5
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Cyberlindnera saturnus IAM 4094
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Wickerhamiella pararugosa IFO 0966
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Ustilago crus-galli F-B-6
-
2-methylcitrate + CoA
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Aspergillus niger
-
IFO 6662
-
Candida gropengiesseri
-
IFO 0569
-
Citeromyces matritensis
-
IFO 0651
-
Cryptococcus neoformans
-
IFO 0545
-
Cutaneotrichosporon curvatus
-
IFO 0732
-
Cyberlindnera saturnus
-
IAM 4094
-
Cyberlindnera saturnus IAM 4094
-
IAM 4094
-
Debaryomyces hansenii
-
IFO 0032
-
Diutina catenulata
-
CBS 565, IFO 0720, CBS 1904, CBS 2015, CBS 6174, OM-102
-
Kluyveromyces marxianus
-
IFO 0586, IFO 0882
-
Lipomyces starkeyi
-
IFO 0678
-
Metschnikowia pulcherrima
-
IFO 0561
-
Mucor rouxianus
-
IFO 5773
-
Neurospora crassa
-
IFO 6067
-
no activity in Candida rugosa
-
IFO 0750, NPA-1, IFO 1364
-
Ogataea angusta
-
IFO 0799
-
Priceomyces haplophilus
-
IFO 0947
-
Pseudomonas aeruginosa
-
-
-
Rhizopus microsporus var. chinensis
-
IAM 6003
-
Rhizopus microsporus var. chinensis IAM 6003
-
IAM 6003
-
Saccharomyces cerevisiae
-
SANK 50182
-
Saccharomyces cerevisiae SANK 50182
-
SANK 50182
-
Saccharomycopsis fibuligera
-
IFO 1711, IFO 1744
-
Schwanniomyces polymorphus
-
IFO 1363
-
Starmerella magnoliae
-
IFO 0661
-
Torulaspora delbrueckii
-
IFO 0381
-
Ustilago crus-galli
-
F-B-6
-
Ustilago crus-galli F-B-6
-
F-B-6
-
Ustilago utriculosa
-
F-B-5
-
Ustilago utriculosa F-B-5
-
F-B-5
-
Vanrija humicola
-
IFO 0753
-
Wickerhamiella pararugosa
-
IFO 0966
-
Wickerhamomyces anomalus
-
IFO 0121
-
Yarrowia lipolytica
-
IFO 1659; synonym Saccharomycopsis lipolytica IFO 1457, IFO 1542
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.002
-
CBS 1904, CBS 2015
Diutina catenulata
0.005
-
OM-102
Diutina catenulata
0.006
-
CBS 6174
Diutina catenulata
0.007
-
IFO 0720
Diutina catenulata
0.007
-
-
Saccharomyces cerevisiae
0.008
-
-
Cryptococcus neoformans
0.009
-
-
Citeromyces matritensis
0.01
-
-
Rhizopus microsporus var. chinensis
0.011
-
-
Mucor rouxianus
0.012
-
-
Aspergillus niger
0.012
-
CBS 565
Diutina catenulata
0.012
-
-
Yarrowia lipolytica
0.014
-
-
Cutaneotrichosporon curvatus
0.014
-
-
Ustilago utriculosa
0.015
-
IFO 1711
Saccharomycopsis fibuligera
0.016
-
-
Debaryomyces hansenii
0.016
-
IFO 1744
Saccharomycopsis fibuligera
0.016
-
-
Torulaspora delbrueckii
0.017
-
-
Cyberlindnera saturnus
0.018
-
-
Neurospora crassa
0.018
-
-
Wickerhamomyces anomalus
0.022
-
-
Wickerhamiella pararugosa
0.023
-
-
Candida gropengiesseri
0.025
-
-
Ogataea angusta
0.027
-
-
Metschnikowia pulcherrima
0.027
-
-
Vanrija humicola
0.028
-
IFO 1457
Yarrowia lipolytica
0.03
-
IFO 1659
Yarrowia lipolytica
0.034
-
IFO 1542
Yarrowia lipolytica
0.038
-
-
Schwanniomyces polymorphus
0.042
-
CBS 0882
Kluyveromyces marxianus
0.053
-
-
Ustilago crus-galli
0.056
-
CBS 0586
Kluyveromyces marxianus
0.065
-
-
Priceomyces haplophilus
0.086
-
-
Starmerella magnoliae
0.116
-
-
Lipomyces starkeyi
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + H2O + oxaloacetate
uses acetyl-CoA in preference to propionyl-CoA
5348
Neurospora crassa
citrate + CoA
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
uses acetyl-CoA in preference to propionyl-CoA
5348
Yarrowia lipolytica
citrate + CoA
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
uses acetyl-CoA in preference to propionyl-CoA
5348
Neurospora crassa IFO 6067
citrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Saccharomyces cerevisiae
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Neurospora crassa
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Aspergillus niger
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Pseudomonas aeruginosa
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Yarrowia lipolytica
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Ogataea angusta
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Lipomyces starkeyi
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Kluyveromyces marxianus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Cryptococcus neoformans
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Vanrija humicola
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Wickerhamiella pararugosa
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Rhizopus microsporus var. chinensis
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Mucor rouxianus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Ustilago utriculosa
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Ustilago crus-galli
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Wickerhamomyces anomalus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Metschnikowia pulcherrima
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Cutaneotrichosporon curvatus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Debaryomyces hansenii
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Cyberlindnera saturnus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Saccharomycopsis fibuligera
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Diutina catenulata
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Candida gropengiesseri
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Schwanniomyces polymorphus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Priceomyces haplophilus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Starmerella magnoliae
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Torulaspora delbrueckii
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Citeromyces matritensis
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
first key enzyme of the methylcitric acid cycle
5348
Saccharomyces cerevisiae
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
first key enzyme of the methylcitric acid cycle
5348
Pseudomonas aeruginosa
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
first key enzyme of the methylcitric acid cycle
5348
Yarrowia lipolytica
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Rhizopus microsporus var. chinensis IAM 6003
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Neurospora crassa IFO 6067
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Mucor rouxianus IFO 5773
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Saccharomyces cerevisiae SANK 50182
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
first key enzyme of the methylcitric acid cycle
5348
Saccharomyces cerevisiae SANK 50182
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Ustilago utriculosa F-B-5
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Cyberlindnera saturnus IAM 4094
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Wickerhamiella pararugosa IFO 0966
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Ustilago crus-galli F-B-6
2-methylcitrate + CoA
-
-
-
?
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
propanoyl-CoA + H2O + oxaloacetate
Neurospora crassa
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Aspergillus niger
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Ogataea angusta
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Lipomyces starkeyi
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Kluyveromyces marxianus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Cryptococcus neoformans
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Vanrija humicola
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Wickerhamiella pararugosa
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Rhizopus microsporus var. chinensis
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Mucor rouxianus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Ustilago utriculosa
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Ustilago crus-galli
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Wickerhamomyces anomalus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Metschnikowia pulcherrima
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Cutaneotrichosporon curvatus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Debaryomyces hansenii
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Cyberlindnera saturnus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Saccharomycopsis fibuligera
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Diutina catenulata
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Candida gropengiesseri
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Schwanniomyces polymorphus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Priceomyces haplophilus
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Starmerella magnoliae
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Torulaspora delbrueckii
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Citeromyces matritensis
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Saccharomyces cerevisiae
first key enzyme of the methylcitric acid cycle
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Pseudomonas aeruginosa
first key enzyme of the methylcitric acid cycle
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Yarrowia lipolytica
first key enzyme of the methylcitric acid cycle
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Rhizopus microsporus var. chinensis IAM 6003
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Neurospora crassa IFO 6067
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Mucor rouxianus IFO 5773
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Saccharomyces cerevisiae SANK 50182
first key enzyme of the methylcitric acid cycle
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Ustilago utriculosa F-B-5
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Cyberlindnera saturnus IAM 4094
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Wickerhamiella pararugosa IFO 0966
-
2-methylcitrate + CoA
-
-
?
propanoyl-CoA + H2O + oxaloacetate
Ustilago crus-galli F-B-6
-
2-methylcitrate + CoA
-
-
?
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.002
-
CBS 1904, CBS 2015
Diutina catenulata
0.005
-
OM-102
Diutina catenulata
0.006
-
CBS 6174
Diutina catenulata
0.007
-
IFO 0720
Diutina catenulata
0.007
-
-
Saccharomyces cerevisiae
0.008
-
-
Cryptococcus neoformans
0.009
-
-
Citeromyces matritensis
0.01
-
-
Rhizopus microsporus var. chinensis
0.011
-
-
Mucor rouxianus
0.012
-
-
Aspergillus niger
0.012
-
CBS 565
Diutina catenulata
0.012
-
-
Yarrowia lipolytica
0.014
-
-
Cutaneotrichosporon curvatus
0.014
-
-
Ustilago utriculosa
0.015
-
IFO 1711
Saccharomycopsis fibuligera
0.016
-
-
Debaryomyces hansenii
0.016
-
IFO 1744
Saccharomycopsis fibuligera
0.016
-
-
Torulaspora delbrueckii
0.017
-
-
Cyberlindnera saturnus
0.018
-
-
Neurospora crassa
0.018
-
-
Wickerhamomyces anomalus
0.022
-
-
Wickerhamiella pararugosa
0.023
-
-
Candida gropengiesseri
0.025
-
-
Ogataea angusta
0.027
-
-
Metschnikowia pulcherrima
0.027
-
-
Vanrija humicola
0.028
-
IFO 1457
Yarrowia lipolytica
0.03
-
IFO 1659
Yarrowia lipolytica
0.034
-
IFO 1542
Yarrowia lipolytica
0.038
-
-
Schwanniomyces polymorphus
0.042
-
CBS 0882
Kluyveromyces marxianus
0.053
-
-
Ustilago crus-galli
0.056
-
CBS 0586
Kluyveromyces marxianus
0.065
-
-
Priceomyces haplophilus
0.086
-
-
Starmerella magnoliae
0.116
-
-
Lipomyces starkeyi
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + H2O + oxaloacetate
uses acetyl-CoA in preference to propionyl-CoA
5348
Neurospora crassa
citrate + CoA
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
uses acetyl-CoA in preference to propionyl-CoA
5348
Yarrowia lipolytica
citrate + CoA
-
-
-
?
acetyl-CoA + H2O + oxaloacetate
uses acetyl-CoA in preference to propionyl-CoA
5348
Neurospora crassa IFO 6067
citrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Saccharomyces cerevisiae
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Neurospora crassa
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Aspergillus niger
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Pseudomonas aeruginosa
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Yarrowia lipolytica
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Ogataea angusta
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Lipomyces starkeyi
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Kluyveromyces marxianus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Cryptococcus neoformans
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Vanrija humicola
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Wickerhamiella pararugosa
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Rhizopus microsporus var. chinensis
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Mucor rouxianus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Ustilago utriculosa
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Ustilago crus-galli
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Wickerhamomyces anomalus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Metschnikowia pulcherrima
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Cutaneotrichosporon curvatus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Debaryomyces hansenii
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Cyberlindnera saturnus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Saccharomycopsis fibuligera
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Diutina catenulata
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Candida gropengiesseri
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Schwanniomyces polymorphus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Priceomyces haplophilus
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Starmerella magnoliae
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Torulaspora delbrueckii
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Citeromyces matritensis
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
first key enzyme of the methylcitric acid cycle
5348
Saccharomyces cerevisiae
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
first key enzyme of the methylcitric acid cycle
5348
Pseudomonas aeruginosa
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
first key enzyme of the methylcitric acid cycle
5348
Yarrowia lipolytica
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Rhizopus microsporus var. chinensis IAM 6003
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Neurospora crassa IFO 6067
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Mucor rouxianus IFO 5773
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Saccharomyces cerevisiae SANK 50182
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
first key enzyme of the methylcitric acid cycle
5348
Saccharomyces cerevisiae SANK 50182
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Ustilago utriculosa F-B-5
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Cyberlindnera saturnus IAM 4094
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Wickerhamiella pararugosa IFO 0966
2-methylcitrate + CoA
-
-
-
?
propanoyl-CoA + H2O + oxaloacetate
-
5348
Ustilago crus-galli F-B-6
2-methylcitrate + CoA
-
-
-
?
Other publictions for EC 2.3.3.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735578
Eniyan
Cloning, expression, purificat ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Asian Pac. J. Trop. Med.
8
19-23
2015
-
-
1
-
-
-
-
-
1
-
2
2
-
161
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
2
2
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
735795
Kobayashi
Gene identification and functi ...
Aspergillus niger, Aspergillus niger WU-2223L
Biosci. Biotechnol. Biochem.
77
1492-1498
2013
-
-
1
-
-
-
-
-
1
-
1
2
-
5
-
-
1
-
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
1
-
-
-
-
4
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
720336
Chittori
Crystal structure of Salmonell ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Struct. Biol.
174
58-68
2011
-
-
-
-
-
-
2
4
-
-
-
-
-
4
-
-
-
-
-
-
-
-
3
1
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
4
-
-
-
-
-
-
-
-
-
-
-
-
3
1
-
-
1
2
-
-
-
-
-
-
-
-
2
2
704332
Rocco
In Salmonella enterica, 2-meth ...
Salmonella enterica, Salmonella enterica JE2170
J. Bacteriol.
192
771-778
2010
-
-
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
705576
Domin
Methylcitrate cycle activation ...
Fusarium solani, Fusarium verticillioides
Microbiology
155
3903-3912
2009
-
-
2
-
-
-
-
8
-
-
2
2
-
9
-
-
2
-
-
-
4
-
4
-
-
2
-
4
-
2
-
2
-
-
-
-
-
2
2
-
-
-
-
-
-
8
-
-
2
2
-
-
-
2
-
-
4
-
4
-
-
2
-
4
-
2
-
-
-
2
2
-
-
-
703115
Ibrahim-Granet
Methylcitrate synthase from As ...
Aspergillus fumigatus
Cell. Microbiol.
10
134-148
2008
-
1
1
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
6
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
6
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
705770
Fleck
Characterization of an acyl-Co ...
Aspergillus nidulans
Mol. Microbiol.
68
642-656
2008
-
-
-
-
-
-
-
-
-
-
-
1
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
671529
Ewering
Occurrence and expression of t ...
Cupriavidus necator, Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
Appl. Microbiol. Biotechnol.
71
80-89
2006
-
-
1
-
-
-
-
2
-
-
1
-
-
5
-
-
-
-
-
-
-
-
8
1
1
-
-
-
1
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
8
1
1
-
-
-
1
-
-
1
-
-
-
-
-
-
675795
Ewering
Metabolic engineering of strai ...
Cupriavidus necator, Cupriavidus necator H16 / ATCC 23440 / NCIB 10442 / S-10-1
Metab. Eng.
8
587-602
2006
-
-
1
-
-
-
-
-
-
-
-
-
-
46
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
661700
Maerker
Methylcitrate synthase from As ...
Aspergillus fumigatus
FEBS J.
272
3615-3630
2005
-
-
-
-
1
-
2
5
1
-
2
1
-
5
-
-
1
-
-
2
2
-
3
1
1
-
2
-
1
-
1
-
1
2
-
-
-
-
-
-
1
-
-
2
1
5
1
-
2
1
-
-
-
1
-
2
2
-
3
1
1
-
2
-
1
-
1
2
-
-
-
-
-
-
488087
Karlsson
Rhodothermus marinus: a thermo ...
Escherichia coli, Pseudomonas aeruginosa, Rhodothermus marinus
Extremophiles
6
51-56
2002
-
-
2
-
-
-
-
4
-
-
-
3
-
3
-
-
1
-
-
-
1
-
8
2
1
1
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
4
-
-
-
3
-
-
-
1
-
-
1
-
8
2
1
1
1
-
-
-
-
-
-
-
-
-
-
-
488174
Braemer
Identification of the 2-methyl ...
Aspergillus nidulans, Burkholderia cepacia, Burkholderia cepacia contig261, Cupriavidus metallidurans, Escherichia coli, Escherichia coli O157:H17, Legionella pneumophila, Neisseria meningitidis, Paraburkholderia sacchari, Paraburkholderia sacchari IPT101, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas fluorescens contig267, Pseudomonas putida, Pseudomonas putida contig10768, Pseudomonas putida KT 2240, Pseudomonas syringae, Pseudomonas syringae contig5376, Pyrococcus furiosus, Salmonella enterica, Shewanella putrefaciens, Shewanella putrefaciens contig93, Vibrio cholerae
Appl. Environ. Microbiol.
68
271-279
2002
-
-
1
-
-
-
-
-
-
-
1
33
-
74
-
-
-
-
-
-
-
-
41
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
33
-
-
-
-
-
-
-
-
41
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
488175
Brock
Oxidation of propionate to pyr ...
Cupriavidus metallidurans, Escherichia coli, Salmonella enterica, Yarrowia lipolytica
Eur. J. Biochem.
269
6184-6194
2002
-
-
2
-
-
-
-
-
-
-
1
5
-
7
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
1
5
-
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
488176
Claes
Identification of two prpDBC g ...
Aspergillus nidulans, Corynebacterium glutamicum, Cupriavidus metallidurans, Escherichia coli, Paraburkholderia sacchari, Pseudomonas aeruginosa, Salmonella enterica, Yarrowia lipolytica
J. Bacteriol.
184
2728-2739
2002
-
-
1
-
-
-
-
-
-
-
2
12
-
15
-
-
-
-
-
-
-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
12
-
-
-
-
-
-
-
-
18
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
488173
Braemer
The methylcitric acid pathway ...
Aspergillus nidulans, Cupriavidus metallidurans, Escherichia coli, Neisseria meningitidis, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas putida KT 2240, Salmonella enterica, Vibrio cholerae
Microbiology
147
2203-2214
2001
-
1
1
-
-
-
-
-
-
-
1
9
-
49
-
-
-
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
9
-
-
-
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
488089
Brock
Methylcitrate synthase from As ...
Aspergillus nidulans
Mol. Microbiol.
35
961-973
2000
-
-
1
-
1
-
2
3
2
1
3
1
-
3
-
1
1
-
-
1
4
-
3
1
1
1
-
2
1
1
-
-
-
-
-
-
-
1
-
-
1
-
-
2
-
3
2
1
3
1
-
-
1
1
-
1
4
-
3
1
1
1
-
2
1
1
-
-
-
-
-
-
-
-
488172
Gerike
-
Citrate synthase and 2-methylc ...
Arthrobacter sp., Escherichia coli, Escherichia coli JM109, no activity in Sus scrofa, Pyrococcus furiosus, Saccharomyces cerevisiae, Salmonella enterica, Thermoplasma acidophilum, Yarrowia lipolytica
Microbiology
144
929-935
1998
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1
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8
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38
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3
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10
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8
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10
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488171
Textor
Propionate oxidation in Escher ...
Escherichia coli, Saccharomyces cerevisiae, Salmonella enterica, Yarrowia lipolytica
Arch. Microbiol.
168
428-436
1997
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1
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6
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10
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1
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1
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6
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1
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1
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1
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1
6
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1
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1
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6
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1
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1
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488170
Pronk
-
Propionate metabolism in Sacch ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae CBS 8066, Yarrowia lipolytica
Microbiology
140
717-722
1994
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4
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3
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5
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5348
Miyakoshi
-
Distribution of the methylcitr ...
Aspergillus niger, Candida gropengiesseri, Citeromyces matritensis, Cryptococcus neoformans, Cutaneotrichosporon curvatus, Cyberlindnera saturnus, Cyberlindnera saturnus IAM 4094, Debaryomyces hansenii, Diutina catenulata, Kluyveromyces marxianus, Lipomyces starkeyi, Metschnikowia pulcherrima, Mucor rouxianus, Neurospora crassa, no activity in Candida rugosa, Ogataea angusta, Priceomyces haplophilus, Pseudomonas aeruginosa, Rhizopus microsporus var. chinensis, Rhizopus microsporus var. chinensis IAM 6003, Saccharomyces cerevisiae, Saccharomyces cerevisiae SANK 50182, Saccharomycopsis fibuligera, Schwanniomyces polymorphus, Starmerella magnoliae, Torulaspora delbrueckii, Ustilago crus-galli, Ustilago crus-galli F-B-6, Ustilago utriculosa, Ustilago utriculosa F-B-5, Vanrija humicola, Wickerhamiella pararugosa, Wickerhamomyces anomalus, Yarrowia lipolytica
Agric. Biol. Chem.
51
2381-2387
1987
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36
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34
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36
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43
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36
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36
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43
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488168
Watson
-
Pseudomonas aeruginosa contain ...
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO, Pseudomonas citronellolis, Pseudomonas putida, Yarrowia lipolytica
Curr. Microbiol.
8
17-21
1983
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5
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11
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1
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14
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5
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1
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14
-
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5344
Uchiyama
Subcellular localization of th ...
Yarrowia lipolytica
Eur. J. Biochem.
125
523-527
1982
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1
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1
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1
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4
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3
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488166
Uchiyama
-
Properties of methylcitrate sy ...
Escherichia coli, Yarrowia lipolytica
Agric. Biol. Chem.
40
1411-1418
1976
1
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9
5
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3
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3
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2
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1
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2
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9
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1
1
1
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1
1
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1
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9
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5
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3
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3
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1
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2
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9
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1
1
1
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1
1
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488165
Tabuchi
-
Methylcitrate condensing and m ...
Yarrowia lipolytica
Agric. Biol. Chem.
39
2035-2042
1975
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1
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1
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1
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5
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1
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