Activating Compound | Comment | Organism | Structure |
---|---|---|---|
isocitrate | 1 mM, relative activity 101% | Yarrowia lipolytica |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | slight inhibition | Yarrowia lipolytica | |
ATP | - |
Yarrowia lipolytica | |
H2O2 | - |
Yarrowia lipolytica | |
Hg2+ | - |
Yarrowia lipolytica | |
Monoiodoacetamide | - |
Yarrowia lipolytica | |
NADH | - |
Yarrowia lipolytica | |
NADPH | - |
Yarrowia lipolytica | |
p-chloromercuribenzoate | - |
Yarrowia lipolytica | |
Zn2+ | - |
Yarrowia lipolytica |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0029 | - |
acetyl-CoA | - |
Yarrowia lipolytica | |
0.0053 | - |
propionyl-CoA | - |
Yarrowia lipolytica | |
0.022 | - |
butyryl-CoA | - |
Yarrowia lipolytica | |
0.025 | - |
oxaloacetate | - |
Yarrowia lipolytica | |
0.025 | - |
valeryl-CoA | - |
Yarrowia lipolytica |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | 1 mM, relative activity 104% | Yarrowia lipolytica | |
Fe2+ | 0.02 mM, relative activity 104% | Yarrowia lipolytica | |
Mg2+ | 1 mM, relative activity 102% | Yarrowia lipolytica |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
propanoyl-CoA + H2O + oxaloacetate | Yarrowia lipolytica | physiological role of the methylcitric acid cycle is a catabolic reaction sequence concerning the oxidation of propionate into pyruvate, regulatory enzyme of this cycle | 2-methylcitrate + CoA | - |
? | |
propanoyl-CoA + H2O + oxaloacetate | Escherichia coli | first key enzyme of the methylcitric acid cycle | 2-methylcitrate + CoA | - |
? | |
propanoyl-CoA + H2O + oxaloacetate | Yarrowia lipolytica | first key enzyme of the methylcitric acid cycle | 2-methylcitrate + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Yarrowia lipolytica | - |
formerly Candida lipolytica | - |
Yarrowia lipolytica | - |
IFO 1659 | - |
Purification (Comment) | Organism |
---|---|
- |
Yarrowia lipolytica |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.436 | - |
substrate propionyl-CoA | Yarrowia lipolytica |
0.623 | - |
substrate acetyl-CoA | Yarrowia lipolytica |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + oxaloacetate | - |
Yarrowia lipolytica | citrate + CoA | - |
? | |
additional information | enzyme is specific for oxaloacetate, does not catalyze liberation of CoA from acetyl- or propionyl-CoA in presence of glyoxylate, pyruvate or alpha-ketoglutarate, isobutyryl-CoA and isovaleryl-CoA are no substrates | Yarrowia lipolytica | ? | - |
? | |
n-butyryl-CoA + H2O + oxaloacetate | - |
Yarrowia lipolytica | 2-ethylcitrate + CoA | - |
r | |
n-valeryl-CoA + H2O + oxaloacetate | - |
Yarrowia lipolytica | 2-propylcitrate + CoA | - |
r | |
propanoyl-CoA + H2O + oxaloacetate | - |
Escherichia coli | 2-methylcitrate + CoA | - |
? | |
propanoyl-CoA + H2O + oxaloacetate | - |
Yarrowia lipolytica | 2-methylcitrate + CoA | - |
? | |
propanoyl-CoA + H2O + oxaloacetate | physiological role of the methylcitric acid cycle is a catabolic reaction sequence concerning the oxidation of propionate into pyruvate, regulatory enzyme of this cycle | Yarrowia lipolytica | 2-methylcitrate + CoA | - |
? | |
propanoyl-CoA + H2O + oxaloacetate | first key enzyme of the methylcitric acid cycle | Escherichia coli | 2-methylcitrate + CoA | - |
? | |
propanoyl-CoA + H2O + oxaloacetate | first key enzyme of the methylcitric acid cycle | Yarrowia lipolytica | 2-methylcitrate + CoA | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
45 | - |
- |
Yarrowia lipolytica |
Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
---|---|---|---|
10 | 50 | - |
Yarrowia lipolytica |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
activity completely lost after 10 min | Yarrowia lipolytica |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | 8.5 | - |
Yarrowia lipolytica |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 9.5 | - |
Yarrowia lipolytica |