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Literature summary for 2.3.3.16 extracted from

  • Sheldon, J.R.; Marolda, C.L.; Heinrichs, D.E.
    TCA cycle activity in Staphylococcus aureus is essential for iron-regulated synthesis of staphyloferrin A, but not staphyloferrin B: the benefit of a second citrate synthase (2014), Mol. Microbiol., 92, 824-839.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + H2O + oxaloacetate Staphylococcus aureus
-
 citrate + CoA
-
 ?
acetyl-CoA + H2O + oxaloacetate Staphylococcus aureus Newman
-
 citrate + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
-
-
Staphylococcus aureus Newman
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + oxaloacetate
-
 Staphylococcus aureus citrate + CoA
-
 ?
acetyl-CoA + H2O + oxaloacetate
-
 Staphylococcus aureus Newman citrate + CoA
-
 ?

Synonyms

Synonyms Comment Organism
CitZ
-
 Staphylococcus aureus

Expression

Organism Comment Expression
Staphylococcus aureus enzyme expression is downregulated during iron starvation down

General Information

General Information Comment Organism
malfunction citrate synthase mutants exhibit altered colony morphology with enhanced pigmentation and reduced colony size and enter stationary phase early than the wild type enzyme Staphylococcus aureus
metabolism the enzyme is part of the tricarboxylic acid cycle Staphylococcus aureus
physiological function the enzyme is required for maximal virulence Staphylococcus aureus