Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Sulfolobus acidocaldarius |
Protein Variants | Comment | Organism |
---|---|---|
additional information | the RAM domain is responsible for enzyme inhibition. A mutant enzyme lacking the RAM domain is insensitive to inhibition by lysine | Sulfolobus acidocaldarius |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lysine | mutant enzyme lacking the RAM domain is insensitive to inhibition by lysine | Sulfolobus acidocaldarius |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + 2-oxoglutarate | Sulfolobus acidocaldarius | the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway | (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? | |
acetyl-CoA + H2O + 2-oxoglutarate | Sulfolobus acidocaldarius DSM 639 | the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway | (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sulfolobus acidocaldarius | Q4J989 | - |
- |
Sulfolobus acidocaldarius DSM 639 | Q4J989 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + 2-oxoglutarate | - |
Sulfolobus acidocaldarius | (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? | |
acetyl-CoA + H2O + 2-oxoglutarate | the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway | Sulfolobus acidocaldarius | (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? | |
acetyl-CoA + H2O + 2-oxoglutarate | - |
Sulfolobus acidocaldarius DSM 639 | (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? | |
acetyl-CoA + H2O + 2-oxoglutarate | the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway | Sulfolobus acidocaldarius DSM 639 | (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
saci_1304 | - |
Sulfolobus acidocaldarius |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme catalyzes the first and committed step of the alpha-aminoadipate pathway | Sulfolobus acidocaldarius |