Literature summary for 2.3.3.14 extracted from

Andi, B.; West, A.H.; Cook, P.F.
Regulatory mechanism of Histidine-tagged homocitrate synthase from Saccharomyces cerevisiae: I. KINETIC STUDIES (2005), J. Biol. Chem., 280, 31624-31632.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Lys	feedback inhibitor, competitive versus 2-oxoglutarate and linear in the physiological range of lysine concentrations up to 5 mM	Saccharomyces cerevisiae
Na+	activator at low concentrations, inhibitor at high concentrations, inhibition and activation can occur simultaneously, inhibition by Na+ is eliminated at high concentrations of acetyl-CoA	Saccharomyces cerevisiae

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Na+	activator at low concentrations, inhibitor at high concentrations, inhibition and activation can occur simultaneously, inhibition by Na+ is eliminated at high concentrations of acetyl-CoA	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + H2O + 2-oxoglutarate	-	Saccharomyces cerevisiae	2-hydroxybutane-1,2,4-tricarboxylate + CoA	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	-	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)