Inhibitors | Comment | Organism | Structure |
---|---|---|---|
isoleucine | inhibited by leucine and isoleucine. Leucine is a more effective inhibitor | Thermus thermophilus | |
leucine | inhibited by leucine and isoleucine. Leucine is a more effective inhibitor | Thermus thermophilus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.023 | - |
acetyl-CoA | pH 8.0, 50°C | Thermus thermophilus | |
0.054 | - |
3-methyl-2-oxobutanoate | pH 8.0, 50°C | Thermus thermophilus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | Thermus thermophilus | enzyme of the branched-chain amino acid biosynthetic gene cluster. The enzyme is involved in biosynthesis of leucine and isoleucine | (2S)-2-isopropylmalate + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Thermus thermophilus | Q72JC9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | - |
Thermus thermophilus | (2S)-2-isopropylmalate + CoA | - |
? | |
acetyl-CoA + 3-methyl-2-oxobutanoate + H2O | enzyme of the branched-chain amino acid biosynthetic gene cluster. The enzyme is involved in biosynthesis of leucine and isoleucine | Thermus thermophilus | (2S)-2-isopropylmalate + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IPMS | - |
Thermus thermophilus |
TT_C0849 | - |
Thermus thermophilus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.2 | - |
3-methyl-2-oxobutanoate | pH 8.0, 50°C | Thermus thermophilus | |
1.7 | - |
acetyl-CoA | pH 8.0, 50°C | Thermus thermophilus |
General Information | Comment | Organism |
---|---|---|
metabolism | enzyme of the branched-chain amino acid biosynthetic gene cluster. The enzyme is involved in biosynthesis of leucine and isoleucine | Thermus thermophilus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
22 | - |
3-methyl-2-oxobutanoate | pH 8.0, 50°C | Thermus thermophilus | |
73 | - |
acetyl-CoA | pH 8.0, 50°C | Thermus thermophilus |