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Literature summary for 2.3.3.13 extracted from

  • Larson, E.M.; Idnurm, A.
    Two origins for the gene encoding alpha-isopropylmalate synthase in fungi (2010), PLoS ONE, 5, e11605.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in a Schizosaccharomyces pombe leu3DELTA deletion strain Phycomyces blakesleeanus

Organism

Organism UniProt Comment Textmining
Phycomyces blakesleeanus
-
-
-
Phycomyces blakesleeanus NRRL1555 and UBC21
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Phycomyces blakesleeanus 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Phycomyces blakesleeanus NRRL1555 and UBC21 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?

Synonyms

Synonyms Comment Organism
alpha-IPMS
-
Phycomyces blakesleeanus
alpha-isopropylmalate synthase I
-
Phycomyces blakesleeanus
leuA
-
Phycomyces blakesleeanus

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the first step in the biosynthesis of leucine Phycomyces blakesleeanus