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Literature summary for 2.3.3.13 extracted from

  • Chanchaem, W.; Palittapongarnpim, P.
    A variable number of tandem repeats result in polymorphic alpha -isopropylmalate synthase in Mycobacterium tuberculosis (2002), Tuberculosis, 82, 1-6.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0246
-
2-oxo-3-methylbutanoate
-
Mycobacterium tuberculosis
0.2435
-
acetyl-CoA
-
Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Mycobacterium tuberculosis first enzyme in biosynthesis of L-Leu ?
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Mycobacterium tuberculosis

Storage Stability

Storage Stability Organism
in an icebox, pH 7.5-8.5, 30% loss of activity after 48 h Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Mycobacterium tuberculosis 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Mycobacterium tuberculosis ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37 50 almost full activity Mycobacterium tuberculosis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Mycobacterium tuberculosis

pH Range

pH Minimum pH Maximum Comment Organism
7.1 10 pH 7.1: about 50% of maximal activity, pH 10.0: about 80% of maximal activity Mycobacterium tuberculosis

pH Stability

pH Stability pH Stability Maximum Comment Organism
4
-
enzyme inactive Mycobacterium tuberculosis