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Literature summary for 2.3.3.13 extracted from

  • Casalone, E.; Barberio, C.; Cavalieri, D.; Polsinelli, M.
    Identification by functional analysis of the gene encoding a-isopropylmalate synthase II (LEU9) in Saccharomyces cerevisiae (2000), Yeast, 16, 539-545.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
construction of three knock-out mutants, two carrying a deletion in YOR108w or in Leu4 ORF, and one carrying both the deletions Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Saccharomyces cerevisiae first enzyme in biosynthesis of L-Leu ?
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?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
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Saccharomyces cerevisiae 3-hydroxy-4-methyl-3-carboxypentanoate + CoA i.e. alpha-isopropylmalate ?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Saccharomyces cerevisiae ?
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?