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Literature summary for 2.3.3.13 extracted from

  • Stieglitz, B.I.; Calvo, J.M.
    Distribution of the isopropylmalate pathway to leucine among diverse bacteria (1974), J. Bacteriol., 118, 935-941.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
leucine
-
Hydrogenomonas sp.
leucine
-
Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Salmonella enterica subsp. enterica serovar Typhimurium first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Bacillus subtilis first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Escherichia coli first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Cereibacter sphaeroides first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Bradyrhizobium japonicum first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Pseudomonas fluorescens first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Klebsiella aerogenes first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Pseudomonas aeruginosa first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Proteus vulgaris first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Micrococcus luteus first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Paenibacillus polymyxa first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Chromatium sp. first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Rhodococcus opacus first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Micrococcus sp. first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Methylorubrum extorquens first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Alcaligenes viscolactis first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Hydrogenomonas sp. first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Chromatium sp. D first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Escherichia coli B / ATCC 11303 first enzyme in biosynthesis of L-Leu ?
-
?

Organism

Organism UniProt Comment Textmining
Alcaligenes viscolactis
-
-
-
Bacillus subtilis
-
-
-
Bradyrhizobium japonicum
-
-
-
Cereibacter sphaeroides
-
-
-
Chromatium sp.
-
-
-
Chromatium sp. D
-
-
-
Escherichia coli
-
-
-
Escherichia coli B / ATCC 11303
-
-
-
Hydrogenomonas sp.
-
-
-
Klebsiella aerogenes
-
-
-
Methylorubrum extorquens
-
-
-
Micrococcus luteus
-
-
-
Micrococcus sp.
-
-
-
Paenibacillus polymyxa
-
-
-
Proteus vulgaris
-
-
-
Pseudomonas aeruginosa
-
-
-
Pseudomonas fluorescens
-
-
-
Rhodococcus opacus
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Bacillus subtilis 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Escherichia coli 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Cereibacter sphaeroides 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Bradyrhizobium japonicum 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Pseudomonas fluorescens 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Klebsiella aerogenes 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Pseudomonas aeruginosa 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Proteus vulgaris 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Micrococcus luteus 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Paenibacillus polymyxa 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Chromatium sp. 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Rhodococcus opacus 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Micrococcus sp. 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Methylorubrum extorquens 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Alcaligenes viscolactis 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Hydrogenomonas sp. 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Chromatium sp. D 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Escherichia coli B / ATCC 11303 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Salmonella enterica subsp. enterica serovar Typhimurium ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Bacillus subtilis ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Escherichia coli ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Cereibacter sphaeroides ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Bradyrhizobium japonicum ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Pseudomonas fluorescens ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Klebsiella aerogenes ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Pseudomonas aeruginosa ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Proteus vulgaris ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Micrococcus luteus ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Paenibacillus polymyxa ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Chromatium sp. ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Rhodococcus opacus ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Micrococcus sp. ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Methylorubrum extorquens ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Alcaligenes viscolactis ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Hydrogenomonas sp. ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Chromatium sp. D ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Escherichia coli B / ATCC 11303 ?
-
?