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Literature summary for 2.3.3.13 extracted from

  • Kohlhaw, G.; Leary, T.R.; Umbarger, H.E.
    alpha-Isopropylmalate synthase from Salmonella typhimurium. Purification and properties (1969), J. Biol. Chem., 244, 2218-2225.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-Oxo-isohexanoate
-
Salmonella enterica subsp. enterica serovar Typhimurium
EDTA
-
Salmonella enterica subsp. enterica serovar Typhimurium
Hg2+
-
Salmonella enterica subsp. enterica serovar Typhimurium
leucine end-product inhibition, non-competitive with respect to 2-oxo-3-methylbutanoate and competitive with respect to acetyl-CoA, more sensitive at pH 6.5 than pH 8.5 Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.06
-
2-oxo-3-methylbutanoate with acetyl-CoA as cosubstrate Salmonella enterica subsp. enterica serovar Typhimurium
0.2
-
acetyl-CoA
-
Salmonella enterica subsp. enterica serovar Typhimurium
1.1
-
2-oxobutanoate
-
Salmonella enterica subsp. enterica serovar Typhimurium
10
-
pyruvate
-
Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Salmonella enterica subsp. enterica serovar Typhimurium first enzyme in biosynthesis of L-Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Salmonella enterica subsp. enterica serovar Typhimurium CV-19 first enzyme in biosynthesis of L-Leu ?
-
?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium CV-19
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
14.5
-
-
Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium CV-19 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Salmonella enterica subsp. enterica serovar Typhimurium ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Salmonella enterica subsp. enterica serovar Typhimurium CV-19 ?
-
?
2-oxo-butanoate + acetyl-CoA + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium 2-ethyl-2-hydroxysuccinic acid + CoA
-
?
2-oxo-butanoate + acetyl-CoA + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium CV-19 2-ethyl-2-hydroxysuccinic acid + CoA
-
?
pyruvate + acetyl-CoA + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium 2-hydroxy-2-methylsuccinic acid + CoA
-
?
pyruvate + acetyl-CoA + H2O
-
Salmonella enterica subsp. enterica serovar Typhimurium CV-19 2-hydroxy-2-methylsuccinic acid + CoA
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Salmonella enterica subsp. enterica serovar Typhimurium