Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-Oxo-isohexanoate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
EDTA | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
Hg2+ | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
leucine | end-product inhibition, non-competitive with respect to 2-oxo-3-methylbutanoate and competitive with respect to acetyl-CoA, more sensitive at pH 6.5 than pH 8.5 | Salmonella enterica subsp. enterica serovar Typhimurium |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
2-oxo-3-methylbutanoate | with acetyl-CoA as cosubstrate | Salmonella enterica subsp. enterica serovar Typhimurium | |
0.2 | - |
acetyl-CoA | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
1.1 | - |
2-oxobutanoate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
10 | - |
pyruvate | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxo-3-methylbutanoate + acetyl-CoA + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | first enzyme in biosynthesis of L-Leu | ? | - |
? | |
2-oxo-3-methylbutanoate + acetyl-CoA + H2O | Salmonella enterica subsp. enterica serovar Typhimurium CV-19 | first enzyme in biosynthesis of L-Leu | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhimurium CV-19 | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
14.5 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxo-3-methylbutanoate + acetyl-CoA + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 3-hydroxy-4-methyl-3-carboxypentanoate + CoA | - |
? | |
2-oxo-3-methylbutanoate + acetyl-CoA + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium CV-19 | 3-hydroxy-4-methyl-3-carboxypentanoate + CoA | - |
? | |
2-oxo-3-methylbutanoate + acetyl-CoA + H2O | first enzyme in biosynthesis of L-Leu | Salmonella enterica subsp. enterica serovar Typhimurium | ? | - |
? | |
2-oxo-3-methylbutanoate + acetyl-CoA + H2O | first enzyme in biosynthesis of L-Leu | Salmonella enterica subsp. enterica serovar Typhimurium CV-19 | ? | - |
? | |
2-oxo-butanoate + acetyl-CoA + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-ethyl-2-hydroxysuccinic acid + CoA | - |
? | |
2-oxo-butanoate + acetyl-CoA + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium CV-19 | 2-ethyl-2-hydroxysuccinic acid + CoA | - |
? | |
pyruvate + acetyl-CoA + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | 2-hydroxy-2-methylsuccinic acid + CoA | - |
? | |
pyruvate + acetyl-CoA + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium CV-19 | 2-hydroxy-2-methylsuccinic acid + CoA | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
- |
Salmonella enterica subsp. enterica serovar Typhimurium |