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Literature summary for 2.3.3.13 extracted from

  • Hill, F.; Schlegel, H.G.
    The alpha-isopropylmalate synthetase of Hydrogenomonas H 16 (1969), Arch. Mikrobiol., 68, 1-17.
    View publication on PubMed
Search for more literature for 2.3.3.13

Inhibitors

Inhibitors Comment Organism Structure
5',5',5'-trifluoroleucine
-
 Hydrogenomonas sp.
leucine non-competitive, sensitivity is maximal at pH 7.2 and negligible at pH 8.4 Hydrogenomonas sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Hydrogenomonas sp. first enzyme in biosynthesis of L-Leu ?
-
 ?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Hydrogenomonas sp. repression by Leu ?
-
 ?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Hydrogenomonas sp. H16 first enzyme in biosynthesis of L-Leu ?
-
 ?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Hydrogenomonas sp. H16 repression by Leu ?
-
 ?

Organism

Organism UniProt Comment Textmining
Hydrogenomonas sp.
-
-
-
Hydrogenomonas sp. H16
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
 Hydrogenomonas sp. 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
 ?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
 Hydrogenomonas sp. H16 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
 ?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Hydrogenomonas sp. ?
-
 ?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O repression by Leu Hydrogenomonas sp. ?
-
 ?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O first enzyme in biosynthesis of L-Leu Hydrogenomonas sp. H16 ?
-
 ?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O repression by Leu Hydrogenomonas sp. H16 ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.4
-
-
 Hydrogenomonas sp.