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Literature summary for 2.3.3.13 extracted from

  • Wiegel, J.
    Mn++-specific reactivation of EDTA inactivated alpha-isopropylmalate synthase from Alcaligenes eutrophus H 16 (1978), Biochem. Biophys. Res. Commun., 82, 907-912.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
EDTA Mn2+ plus dithiothreitol restores activity, 2-oxo-3-methylbutanoate prevents inactivation Cupriavidus necator

Metals/Ions

Metals/Ions Comment Organism Structure
additional information enzyme contains a metal ion Cupriavidus necator

Organism

Organism UniProt Comment Textmining
Cupriavidus necator
-
-
-
Cupriavidus necator H 16
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Cupriavidus necator 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Cupriavidus necator H 16 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?