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Literature summary for 2.3.3.13 extracted from

  • Allison, M.J.; Baetz, A.L.; Wiegel, J.
    Alternative pathways for biosynthesis of leucine and other amino acids in Bacteroides ruminicola and Bacteroides fragilis (1984), Appl. Environ. Microbiol., 48, 1111-1117.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Isovalerate moderate Prevotella ruminicola
leucine
-
Bacteroides fragilis
leucine strong Prevotella ruminicola

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Bacteroides fragilis involved in Leu biosynthesis ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Prevotella ruminicola involved in Leu biosynthesis ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Prevotella ruminicola 23 involved in Leu biosynthesis ?
-
?

Organism

Organism UniProt Comment Textmining
Bacteroides fragilis
-
ATCC 23745
-
Prevotella ruminicola
-
-
-
Prevotella ruminicola 23
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Bacteroides fragilis 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Prevotella ruminicola 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Prevotella ruminicola 23 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O involved in Leu biosynthesis Bacteroides fragilis ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O involved in Leu biosynthesis Prevotella ruminicola ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O involved in Leu biosynthesis Prevotella ruminicola 23 ?
-
?