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Literature summary for 2.3.3.13 extracted from

  • Wiegel, J.
    Leucine biosynthesis in Alcaligenes eutrophus H16: influence of amino acid additions on the formation of active alpha-isopropylmalate synthase and alpha-acetohydroxy acid synthase (1985), Arch. Microbiol., 142, 194-199.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
additional information the addition of 5 mM valine plus isoleucine with and without 5 mM threonine caused a 4-6.6fold increase in the formation of active enzyme Cupriavidus necator

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Cupriavidus necator
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Cupriavidus necator the enzyme is regulated by the level of Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Cupriavidus necator involved in Leu biosynthesis ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Cupriavidus necator H 16 the enzyme is regulated by the level of Leu ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O Cupriavidus necator H 16 involved in Leu biosynthesis ?
-
?

Organism

Organism UniProt Comment Textmining
Cupriavidus necator
-
-
-
Cupriavidus necator H 16
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:acetate-grown cell unusually high specific activity of enzyme Cupriavidus necator
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Cupriavidus necator 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O
-
Cupriavidus necator H 16 3-hydroxy-4-methyl-3-carboxypentanoate + CoA
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O the enzyme is regulated by the level of Leu Cupriavidus necator ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O involved in Leu biosynthesis Cupriavidus necator ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O the enzyme is regulated by the level of Leu Cupriavidus necator H 16 ?
-
?
2-oxo-3-methylbutanoate + acetyl-CoA + H2O involved in Leu biosynthesis Cupriavidus necator H 16 ?
-
?