Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | - |
Candida maltosa | |
Cu2+ | - |
Candida maltosa | |
Hg2+ | - |
Candida maltosa | |
K+ | at high concentrations, stimulation at lower concentrations | Candida maltosa | |
leucine | competitive with respect to 2-oxo-3-methylbutanoate, non-competitive with respect to acetyl-CoA | Candida maltosa | |
Zn2+ | - |
Candida maltosa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | - |
Candida maltosa | |
0.064 | - |
acetyl-CoA | - |
Candida maltosa | |
0.57 | - |
2-oxo-3-methylbutanoate | - |
Candida maltosa |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | strongly dependent on the presence of monovalent cations, K+ is most effective | Candida maltosa | |
K+ | Km: 80 mM, inhibitory at higher concentrations | Candida maltosa | |
Li+ | can partially replace K+ in activation | Candida maltosa | |
Rb+ | can partially replace Rb+ in activation | Candida maltosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxo-3-methylbutanoate + acetyl-CoA + H2O | Candida maltosa | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida maltosa | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-oxo-3-methylbutanoate + acetyl-CoA + H2O | - |
Candida maltosa | 3-hydroxy-4-methyl-3-carboxypentanoate + CoA | - |
? | |
2-oxo-3-methylbutanoate + acetyl-CoA + H2O | - |
Candida maltosa | ? | - |
? | |
2-oxo-butanoate + acetyl-CoA + H2O | - |
Candida maltosa | 2-ethyl-2-hydroxysuccinic acid + CoA | - |
? | |
pyruvate + acetyl-CoA + H2O | - |
Candida maltosa | 2-hydroxy-2-methylsuccinic acid + CoA | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.8 | - |
Candida maltosa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.81 | - |
leucine | competitive, with respect to 2-oxo-3-methylbutanoate | Candida maltosa | |
1.3 | - |
leucine | non-competitive, with respect to acetyl-CoA | Candida maltosa | |
230 | - |
K+ | at high concentration | Candida maltosa |