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Literature summary for 2.3.3.10 extracted from

  • Cheng, S.; Wang, X.; Xu, F.; Chen, Q.; Tao, T.; Lei, J.; Zhang, W.; Liao, Y.; Chang, J.; Li, X.
    Cloning, expression profiling and functional analysis of CnHMGS, a gene encoding 3-hydroxy-3-methylglutaryl coenzyme A synthase from Chamaemelum nobile (2016), Molecules, 21, 316 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli strain DH5a Chamaemelum nobile

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50100
-
 calculated from sequence Chamaemelum nobile

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + H2O + acetoacetyl-CoA Chamaemelum nobile
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Chamaemelum nobile A0A140GL76
-
-

Source Tissue

Source Tissue Comment Organism Textmining
flower preferentially expressed in flowers and roots Chamaemelum nobile
-
root preferentially expressed in flowers and roots Chamaemelum nobile
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + H2O + acetoacetyl-CoA
-
 Chamaemelum nobile (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Synonyms

Synonyms Comment Organism
3-hydroxy-3-methylglutaryl coenzyme A synthase
-
 Chamaemelum nobile
HMGS
-
 Chamaemelum nobile

pI Value

Organism Comment pI Value Maximum pI Value
Chamaemelum nobile calculated from sequence
-
 6.05

Expression

Organism Comment Expression
Chamaemelum nobile expression of 3-hydroxy-3-methylglutaryl coenzyme A synthase can be upregulated by exogenous elicitors, including methyl jasmonate and salicylic acid, suggesting that CnHMGS is elicitor-responsive up

General Information

General Information Comment Organism
evolution the sequence of the 3-hydroxy-3-methylglutaryl coenzyme A synthase from Chamaemelum nobile is highly homologous to those of HMGS proteins from other plant species. Phylogenetic tree analysis reveals that CnHMGS clusters with the 3-hydroxy-3-methylglutaryl coenzyme A synthase of asteraceae in the dicotyledon clade Chamaemelum nobile
metabolism the enzyme catalyze the crucial step in the mevalonate pathway in plants Chamaemelum nobile