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Literature summary for 2.3.3.10 extracted from
- Crystal structure of the HMG-CoA synthase MvaS from the Gram-negative bacterium Myxococcus xanthus (2016), ChemBioChem, 17, 1257-1262 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli BL21(DE3) | Myxococcus xanthus |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| sitting-drop vapor-diffusion method, crystal structures of MvaS, the HMGCS from Myxococcus xanthus, in complex with CoA and acetylated active site Cys115, with the second substrate acetoacetyl CoA and with the product of the condensation reaction, 3-hydroxy-3-methylglutaryl CoA | Myxococcus xanthus |
General Stability
| General Stability | Organism |
|---|---|
| dimerization plays a role in the formation and stability of the active site | Myxococcus xanthus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Myxococcus xanthus | Q1D4I1 | - |
- |
| Myxococcus xanthus DK 1622 | Q1D4I1 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Myxococcus xanthus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HMG-CoA synthase | - |
Myxococcus xanthus |
| mvaS | - |
Myxococcus xanthus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | in myxobacteria, the enzyme is involved in an alternative and acetyl-CoA-dependent isovaleryl CoA biosynthesis pathway | Myxococcus xanthus |
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