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Literature summary for 2.3.3.10 extracted from

  • Wang, F.; Xiang, H.; Fischer, G.; Liu, Z.; Dupont, M.J.; Hogan, Q.H.; Yu, H.
    HMG-CoA synthase isoenzymes 1 and 2 localize to satellite glial cells in dorsal root ganglia and are differentially regulated by peripheral nerve injury (2016), Brain Res., 1652, 62-70 .
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus P17425
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Rattus norvegicus P22791
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Source Tissue

Source Tissue Comment Organism Textmining
glial cell satellite glial cells in dorsal root ganglia. HMGCS1 but not HMGCS2 immunoreactivity in satellite glial cells is reduced in the fifth lumbar (L5) dorsal root ganglion that contain axotomized neurons following L5 spinal nerve ligation in rats. HMGCS1 protein level in axotomized L5 dorsal root ganglia is reduced after spinal nerve ligation to 66% at 3 days and 58% at 28 days of its level in control samples, whereas HMGCS2 protein is comparable between injured and control dorsal root ganglia Rattus norvegicus
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Synonyms

Synonyms Comment Organism
HMG-CoA synthase
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 Rattus norvegicus
HMGCS1
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 Rattus norvegicus
HMGCS2
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 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus HMGCS1 expression is downregulated in dorsal root ganglia after spinal nerve injury down