Literature summary for 2.3.3.10 extracted from

Camarero, N.; Mascaro, C.; Mayordomo, C.; Vilardell, F.; Haro, D.; Marrero, P.F.
Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer (2006), Mol. Cancer Res., 4, 645-653.

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Application

Application	Comment	Organism
medicine	expression of isoform HMGCS2 is down-regulated in 90% of Myc-dependent colon and rectum tumors. Protein expression is down-regulated preferentially in moderately and poorly differentiated carcinomas. In addition, it is also down-regulated in 80% of small intestine Myc-independent tumors	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform HMGCS2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Caco-2 cell	enzyme is a direct target of c-Myc, which represses hydroxymethylglutaryl-CoA synthase transcriptional activity	Homo sapiens	-
colon	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
HMGCS2	-	Homo sapiens

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Release 2023.1 (January 2023)