BRENDA - Enzyme Database show
show all sequences of 2.3.3.10

3-Hydroxy-3-methylglutaryl coenzyme A synthase

Miziorko, H.M.; Clinkenbeard, K.D.; Reed, W.D.; Lane, M.D.; J. Biol. Chem. 250, 5768-5773 (1975)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
chloride
-
Saccharomyces cerevisiae
potassium phosphate
-
Saccharomyces cerevisiae
Sodium phosphate
-
Saccharomyces cerevisiae
sulfate
-
Saccharomyces cerevisiae
Inhibitors
Inhibitors
Commentary
Organism
Structure
acetoacetyl-CoA
-
Saccharomyces cerevisiae
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
53000
-
2 * 53000, SDS-PAGE
Gallus gallus
105000
-
sedimentation equlibrium
Gallus gallus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + acetoacetyl-CoA + H2O
Gallus gallus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
Gallus gallus
-
acetyl-CoA + acetoacetyl-CoA + H2O
Saccharomyces cerevisiae
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
Saccharomyces cerevisiae
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Gallus gallus
-
-
-
Saccharomyces cerevisiae
-
-
-
Purification (Commentary)
Commentary
Organism
partially
Saccharomyces cerevisiae
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Gallus gallus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + 3'-dephospho-CoA + H2O
-
488098
Gallus gallus
acetyldephospho-CoA + CoA
-
488098
Gallus gallus
?
acetyl-CoA + acetoacetyl-CoA + H2O
-
488098
Gallus gallus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
488098
Gallus gallus
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488098
Saccharomyces cerevisiae
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
488098
Saccharomyces cerevisiae
-
acetyl-CoA + cysteamine + H2O
-
488098
Gallus gallus
? + CoA
-
-
-
?
acetyl-CoA + H2O
-
488098
Gallus gallus
acetate + CoA
-
488098
Gallus gallus
?
Subunits
Subunits
Commentary
Organism
dimer
2 * 53000, SDS-PAGE
Gallus gallus
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.008
-
acetoacetyl-CoA
-
Saccharomyces cerevisiae
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
chloride
-
Saccharomyces cerevisiae
potassium phosphate
-
Saccharomyces cerevisiae
Sodium phosphate
-
Saccharomyces cerevisiae
sulfate
-
Saccharomyces cerevisiae
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
acetoacetyl-CoA
-
Saccharomyces cerevisiae
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
0.008
-
acetoacetyl-CoA
-
Saccharomyces cerevisiae
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
53000
-
2 * 53000, SDS-PAGE
Gallus gallus
105000
-
sedimentation equlibrium
Gallus gallus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + acetoacetyl-CoA + H2O
Gallus gallus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
Gallus gallus
-
acetyl-CoA + acetoacetyl-CoA + H2O
Saccharomyces cerevisiae
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
Saccharomyces cerevisiae
-
Purification (Commentary) (protein specific)
Commentary
Organism
partially
Saccharomyces cerevisiae
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Gallus gallus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + 3'-dephospho-CoA + H2O
-
488098
Gallus gallus
acetyldephospho-CoA + CoA
-
488098
Gallus gallus
?
acetyl-CoA + acetoacetyl-CoA + H2O
-
488098
Gallus gallus
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
488098
Gallus gallus
-
acetyl-CoA + acetoacetyl-CoA + H2O
-
488098
Saccharomyces cerevisiae
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
488098
Saccharomyces cerevisiae
-
acetyl-CoA + cysteamine + H2O
-
488098
Gallus gallus
? + CoA
-
-
-
?
acetyl-CoA + H2O
-
488098
Gallus gallus
acetate + CoA
-
488098
Gallus gallus
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 53000, SDS-PAGE
Gallus gallus
Other publictions for EC 2.3.3.10
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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9
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1
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1
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2
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1
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4
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16
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1
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1
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16
1
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16
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16
-
1
16
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1
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16
1
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1
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1
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1
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1
1
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10
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3
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-
1
1
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1
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1
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1
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1
1
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3
-
-
1
1
-
-
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-
1
1
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1
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2
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-
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2
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1
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1
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4
1
2
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1
1
2
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1
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1
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3
1
2
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1
2
2
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1
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-
4
1
2
-
1
1
2
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-
-
1
1
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1
1
737238
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Russ. J. Plant Physiol.
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2013
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1
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1
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1
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1
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1
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1
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1
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718933
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1
1
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1
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-
-
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-
3
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1
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1
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1
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1
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1
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2
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15
-
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1
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1
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1
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15
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1
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1
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2
2
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701677
Andrew Skaff
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396
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2010
-
1
1
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-
6
3
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1
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2
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1
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1
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2
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1
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1
3
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1
1
1
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6
3
3
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1
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1
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1
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2
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1
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-
-
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-
-
-
2
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-
1
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2
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2
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1
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1
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706551
Okamura
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2010
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3
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720239
Shafqat
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J. Mol. Biol.
398
497-506
2010
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1
1
17
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2
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5
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1
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4
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17
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4
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706809
Battilana
The 1-deoxy-D: -xylulose 5-pho ...
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Theor. Appl. Genet.
118
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2009
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2
2
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688996
Liu
A natural polymorphism in pero ...
Homo sapiens
Mol. Endocrinol.
22
1078-1092
2008
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1
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1
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1
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1
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1
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706833
Andringa
Mitochondrial protein thiol mo ...
Mus musculus
Toxicol. Lett.
177
188-197
2008
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1
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1
-
1
1
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1
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1
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1
2
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1
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1
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1
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1
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1
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1
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1
-
1
1
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1
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1
2
-
1
-
1
-
-
-
1
-
-
-
1
-
-
1
-
-
687002
Castro
Increased activity of hepatic ...
Homo sapiens
Hepatology
45
1261-1266
2007
-
-
-
-
-
-
-
-
-
-
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3
-
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1
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1
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-
672101
Steussy
A structural limitation on enz ...
Enterococcus faecalis
Biochemistry
45
14407-14414
2006
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1
1
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2
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1
1
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674016
Bearfield
Isolation, endocrine regulatio ...
Ips pini
Insect Mol. Biol.
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Ketogenic HMGCS2 Is a c-Myc ta ...
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Pojer
Structural basis for the desig ...
Brassica juncea
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660322
Sirinupong
Molecular cloning of a new cDN ...
Hevea brasiliensis
Planta
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660323
Nagegowda
Brassica juncea HMG-CoA syntha ...
Brassica juncea, Brassica juncea BjHMGS1, Brassica juncea BjHMGS2, Brassica juncea BjHMGS3, Brassica juncea BjHMGS4
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Steussy
X-ray crystal structures of HM ...
Enterococcus faecalis
Biochemistry
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2005
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Nagegowda
Brassica juncea 3-hydroxy-3-me ...
Brassica juncea
Biochem. J.
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2004
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11
11
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8
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Tomoda
Binding site for fungal beta-l ...
Cricetinae, Rattus norvegicus
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2004
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1
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659403
Campobasso
Staphylococcus aureus 3-hydrox ...
Staphylococcus aureus
J. Biol. Chem.
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2004
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2
1
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Misra
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The influence of conserved aro ...
Gallus gallus
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488122
Sutherlin
Enterococcus faecalis 3-hydrox ...
Blattella germanica, Borreliella burgdorferi, Bos taurus, Enterococcus faecalis, Gallus gallus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Streptococcus pneumoniae, Streptococcus pyogenes, Streptomyces sp., Sus scrofa
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15
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16
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2
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5
1
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18
4
1
-
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1
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-
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-
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Barrero
Low activity of mitochondrial ...
Rattus norvegicus, Rattus norvegicus Sprague-Dawley, Sus scrofa
Arch. Biochem. Biophys.
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2001
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2
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2
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3
-
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-
-
-
-
-
-
-
-
-
-
-
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488121
Casals
3-Hydroxy-3-methylglutaryl coe ...
Blattella germanica
Insect Biochem. Mol. Biol.
31
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2001
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1
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-
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1
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1
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1
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3
-
-
-
-
-
-
-
-
-
-
-
-
-
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488117
Chun
3-Hydroxy-3-methylglutaryl-CoA ...
Arabidopsis thaliana, Blattella germanica, Borreliella burgdorferi, Caenorhabditis elegans, Cricetulus griseus, Gallus gallus, Homo sapiens, Mesocricetus auratus, Methanothermobacter thermautotrophicus, Mus musculus, Pinus sylvestris, Rattus norvegicus, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Sus scrofa
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25
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1
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44
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21
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25
-
-
-
-
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-
-
-
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-
-
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488118
Chun
3-hydroxy-3-methylglutaryl-CoA ...
Arabidopsis thaliana, Blattella germanica, Borreliella burgdorferi, Gallus gallus, Homo sapiens, Methanothermobacter thermautotrophicus, Mus musculus, Pinus sylvestris, Rattus norvegicus, Schizosaccharomyces pombe, Sus scrofa
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14
2
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1
2
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14
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1
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-
14
2
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488119
Vinarov
3-Hydroxy-3-methylglutaryl-coe ...
Gallus gallus
Biochemistry
39
3360-3368
2000
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1
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-
-
-
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1
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660160
Alex
Expression of Brassica juncea ...
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1
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5
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1
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5
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2
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Hegardt
Mitochondrial 3-hydroxy-3-meth ...
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1999
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Madsen
Mitochondrial 3-hydroxy-3-meth ...
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-
Non-radiochemical 3-hydroxy-3 ...
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523-526
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1
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1
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1
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1
1
1
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488116
Cabano
Catalytic properties of recomb ...
Blattella germanica, Bos taurus, Diploptera punctata, Gallus gallus, Locusta migratoria, Saccharomyces cerevisiae
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1
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7
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6
1
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10
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2
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-
1
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-
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2
2
7
4
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1
6
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1
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6
1
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10
-
-
-
-
-
-
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-
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488115
Misra
Evidence for the interaction o ...
Blattella germanica, Bos taurus, Gallus gallus, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae
Biochemistry
35
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1996
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1
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10
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9
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10
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4
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10
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-
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1
1
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1
-
15
10
-
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9
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-
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4
-
-
10
-
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-
-
-
-
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488112
Misra
Avian cytosolic 3-hydroxy-3-me ...
Blattella germanica, Cricetulus griseus, Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus
Biochim. Biophys. Acta
1247
253-259
1995
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1
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6
9
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7
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1
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8
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1
1
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-
1
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-
6
10
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7
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1
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8
-
-
-
-
-
1
1
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-
-
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488113
Montamat
Isolation and characterization ...
Arabidopsis thaliana, Catharanthus roseus, Cricetulus griseus, Gallus gallus, Homo sapiens, Raphanus sativus, Rattus norvegicus
Gene
167
197-201
1995
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1
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1
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7
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1
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5
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8
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1
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6
7
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1
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5
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8
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488114
Scharnagl
A novel assay of cytosolic 3-h ...
Bos taurus, Cricetulus griseus, Gallus gallus, Homo sapiens, Mesocricetus auratus, Rattus norvegicus
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1
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6
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1
4
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2
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8
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6
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2
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7
1
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6
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488111
Rokosz
Human cytoplasmic 3-hydroxy-3- ...
Cricetulus griseus, Gallus gallus, Homo sapiens, Rattus norvegicus
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7
1
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2
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1
1
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2
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10
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7
1
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4
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Greenspan
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Inhibition of 3-hydroxy-3-meth ...
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Misra
Avian 3-hydroxy-3-methylglutar ...
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-
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1
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1
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1
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4
2
1
1
2
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1
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3
3
2
3
-
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488108
Mayer
Inhibition of 3-hydroxy-3-meth ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
169
610-616
1990
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-
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1
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1
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488107
Miziorko
3-Hydroxy-3-methylglutaryl-CoA ...
Gallus gallus
Methods Enzymol.
110
19-26
1988
-
-
-
-
-
-
3
3
1
-
2
1
-
2
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1
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2
1
2
4
1
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2
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3
2
3
1
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2
1
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1
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2
1
2
4
1
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488106
Greenspan
Inhibition of hydroxymethylglu ...
Cricetulus griseus, Gallus gallus, Homo sapiens, Rattus norvegicus
Proc. Natl. Acad. Sci. USA
84
7488-7492
1987
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-
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2
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9
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4
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6
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1
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3
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5
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9
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4
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3
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5
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488103
Lowe
3-Hydroxy-3-methylglutaryl-coe ...
Bos taurus, Gallus gallus, Saccharomyces cerevisiae
Biochem. J.
227
591-599
1985
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-
-
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1
8
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5
-
7
3
-
3
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-
1
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-
2
1
1
4
2
-
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-
1
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-
1
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1
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8
1
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5
-
7
3
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1
-
2
1
1
4
2
-
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-
1
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488104
Lowe
Succinylation and inactivation ...
Bos taurus
Biochem. J.
232
37-42
1985
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-
-
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2
-
1
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1
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1
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1
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2
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1
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2
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1
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1
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1
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2
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1
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-
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488105
Miziorko
-
Active-site directed inhibitio ...
Gallus gallus
Biochemistry
34
3174-3179
1985
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-
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-
2
-
1
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1
-
1
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1
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1
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2
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2
2
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1
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1
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1
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-
1
-
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-
-
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488102
Menahan
Interrelationships between 3-h ...
Gallus gallus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Eur. J. Biochem.
119
287-296
1981
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-
-
-
-
-
2
3
4
-
-
3
-
163
-
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1
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3
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4
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1
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1
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2
1
3
4
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3
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1
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3
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4
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1
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488101
Page
Some properties of 3-hydroxy-3 ...
Bos taurus, Gallus gallus, Saccharomyces cerevisiae
Biochem. J.
173
925-928
1978
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3
1
5
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1
3
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5
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2
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2
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4
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1
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3
1
1
5
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1
3
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2
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2
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4
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488095
Clinkenbeard
-
Cytosolic 3-hydroxy-3-methylgl ...
Gallus gallus, Saccharomyces cerevisiae
Methods Enzymol.
35 B
160-167
1975
-
-
-
-
-
-
6
1
5
-
2
3
-
2
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-
1
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-
1
1
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5
1
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-
1
1
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-
-
-
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6
-
1
5
-
2
3
-
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-
1
-
1
1
-
5
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
488096
Clinkenbeard
-
Cyoplasmic 3-hydroxy-3-methylg ...
Columba livia, Gallus gallus, Meleagris gallopavo, Rattus norvegicus, Saccharomyces cerevisiae
J. Biol. Chem.
250
3124-3135
1975
1
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6
4
12
1
7
5
-
5
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1
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7
1
4
12
1
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3
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1
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6
-
4
12
1
7
5
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1
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7
1
4
12
1
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-
3
-
-
-
-
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-
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-
488097
Middleton
-
3-Hydroxy-3-methylglutaryl-CoA ...
Saccharomyces cerevisiae
Methods Enzymol.
35 B
173-177
1975
-
-
-
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-
1
7
3
-
-
1
1
-
1
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1
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1
2
6
-
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1
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1
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7
1
3
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1
1
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1
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1
2
6
-
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-
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488098
Miziorko
3-Hydroxy-3-methylglutaryl coe ...
Gallus gallus, Saccharomyces cerevisiae
J. Biol. Chem.
250
5768-5773
1975
4
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1
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2
2
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2
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1
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1
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5
1
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1
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4
-
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1
1
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2
2
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1
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1
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5
1
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488099
Reed
Molecular and catalytic proper ...
Gallus gallus, Rattus norvegicus
J. Biol. Chem.
250
3117-3123
1975
-
-
-
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-
5
1
6
1
4
2
-
3
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1
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-
2
1
1
3
1
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1
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-
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5
1
1
6
1
4
2
-
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-
1
-
2
1
1
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
488100
Reed
-
Mitochondrial 3-hydroxy-3-meth ...
Gallus gallus
Methods Enzymol.
35 B
155-160
1975
-
-
-
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-
1
1
2
1
-
2
1
-
1
-
-
1
-
-
1
1
1
2
1
-
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-
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-
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-
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-
1
-
1
-
2
1
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2
1
-
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1
-
1
1
1
2
1
-
-
-
-
-
-
-
-
-
-
-
-
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488094
Cornforth
Substrate stereochemistry of 3 ...
Rattus norvegicus, Saccharomyces cerevisiae
Eur. J. Biochem.
42
591-604
1974
-
-
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-
-
-
-
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2
-
2
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-
1
-
-
1
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4
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-
2
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-
1
-
1
-
-
4
-
-
-
-
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-
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-
-
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488093
Allred
Properties and subcellular dis ...
Cavia porcellus, Gallus gallus, Rattus norvegicus
Biochim. Biophys. Acta
297
22-30
1973
-
-
-
-
-
-
2
-
6
1
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3
-
3
-
-
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-
-
3
12
-
4
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2
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6
1
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3
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3
12
-
4
-
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-
-
-
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-
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488091
Middleton
The kinetic mechanism of 3-hyd ...
Saccharomyces cerevisiae
Biochem. J.
126
35-47
1972
-
-
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15
4
-
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1
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2
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1
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1
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4
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19
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15
19
4
-
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1
-
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1
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1
-
4
-
-
-
-
-
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-
-
-
-
-
-
-
-
488092
Middleton
The purification and some prop ...
Saccharomyces cerevisiae
Biochem. J.
126
27-34
1972
-
-
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-
1
10
-
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-
1
1
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2
-
-
1
-
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1
-
3
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
1
-
10
-
-
-
-
1
1
-
-
-
1
-
-
1
-
3
-
-
-
-
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