Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | - |
Gallus gallus | |
Zn2+ | - |
Gallus gallus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Gallus gallus | 5737 | - |
cytoplasm | - |
Cavia porcellus | 5737 | - |
cytoplasm | - |
Rattus norvegicus | 5737 | - |
mitochondrion | - |
Gallus gallus | 5739 | - |
mitochondrion | - |
Cavia porcellus | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | increases acetoacetate synthesis activity | Gallus gallus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + acetoacetyl-CoA + H2O | Cavia porcellus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Rattus norvegicus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | Gallus gallus | acetoacetate biosynthesis, 3-hydroxy-3-methylglutaryl-CoA pathway | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
guinea pig | - |
Gallus gallus | - |
chicken | - |
Rattus norvegicus | - |
rat | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Gallus gallus | - |
liver | - |
Cavia porcellus | - |
liver | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00083 | - |
mitochondrial pellet | Gallus gallus |
0.00133 | - |
mitochondrial pellet, 0.25 M sucrose | Gallus gallus |
0.00245 | - |
disrupted mitochondria, 0.25 M sucrose | Gallus gallus |
0.00288 | - |
mitochondrial pellet, 0.50 M sucrose | Gallus gallus |
0.00325 | - |
mitochondrial pellet, 0.88 M sucrose | Gallus gallus |
0.00485 | - |
homogenate | Gallus gallus |
0.00567 | - |
disrupted mitochondria, 0.50 M sucrose | Gallus gallus |
0.00792 | - |
disrupted mitochondria, 0.88 M sucrose | Gallus gallus |
0.00922 | - |
mitochondrial supernatant | Gallus gallus |
0.00958 | - |
mitochondrial supernatant, 0.88 M sucrose | Gallus gallus |
0.01053 | - |
mitochondrial supernatant, 0.50 M sucrose | Gallus gallus |
0.0111 | - |
mitochondrial supernatant, 0.25 M sucrose | Gallus gallus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Gallus gallus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Cavia porcellus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | - |
Rattus norvegicus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
acetyl-CoA + acetoacetyl-CoA + H2O | acetoacetate biosynthesis, 3-hydroxy-3-methylglutaryl-CoA pathway | Gallus gallus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? |