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Literature summary for 2.3.2.5 extracted from
- Dipeptidyl-peptidase activity of meprin beta links N-truncation of Abeta with glutaminyl cyclase-catalyzed pGlu-Abeta formation (2018), J. Alzheimers Dis., 66, 359-375 .
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutaminyl-Abeta3-40/42 peptide | Homo sapiens | amyloid-beta peptide Abeta3-40/42 | 5-oxoprolyl-Abeta3-40/42 peptide + NH3 | - |
? |  |
| L-glutaminyl-peptide | Homo sapiens | - |
5-oxoprolyl-peptide + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16769 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| hippocampus | - |
Homo sapiens | - |
| additional information | tissue distribution of enzyme and 5-oxoprolyl-Abeta3-40/42 peptide, detailed overview | Homo sapiens | - |
| neuron | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutaminyl-Abeta3-40/42 peptide | amyloid-beta peptide Abeta3-40/42 | Homo sapiens | 5-oxoprolyl-Abeta3-40/42 peptide + NH3 | - |
? | |
| L-glutaminyl-peptide | - |
Homo sapiens | 5-oxoprolyl-peptide + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutaminyl cyclase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the dipeptidyl-peptidase activity of meprin beta links N-truncation of Abeta with glutaminyl cyclase-catalyzed pGlu-Abeta formation | Homo sapiens |
| physiological function | amyloid-beta peptide Abeta3-40/42 is the precursor of pGlu-Abeta3-40/42 generated by glutaminyl cyclase (QC). The formation of amyloid-beta (Abeta) peptides is causally involved in the development of Alzheimer's disease (AD) | Homo sapiens |
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Release 2023.1 (January 2023)
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