Protein Variants | Comment | Organism |
---|---|---|
H140Q | inactive enzyme | Homo sapiens |
H307Q | mutant enzyme with increased KM-value | Homo sapiens |
H319Q | mutant enzyme with increased KM-value | Homo sapiens |
H330Q | inactive enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
diethyl dicarbonate | rapid inactivation by modification of three essential His residues, at neutral pH, partial reactivation with hydroxylamine | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.1 | - |
Gln-NH2 | wild-type enzyme | Homo sapiens | |
4.3 | - |
Gln-NH2 | mutant enzyme H307Q | Homo sapiens | |
4.9 | - |
Gln-NH2 | mutant enzyme H319Q | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pituitary gland | - |
Homo sapiens | - |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.36 | - |
Gln-NH2 | mutant enzyme H319Q | Homo sapiens | |
0.388 | - |
Gln-NH2 | mutant enzyme H307Q | Homo sapiens | |
0.435 | - |
Gln-NH2 | unmutated enzyme | Homo sapiens |