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Literature summary for 2.3.2.33 extracted from

  • Doerr, A.; Pierre, S.; Zhang, D.D.; Henke, M.; Holland, S.; Scholich, K.
    MYCBP2 Is a guanosine exchange factor for Ran rrotein and determines its localization in neurons of dorsal root ganglia (2015), J. Biol. Chem., 290, 25620-25635 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus stimulation of neurons induces a GTPase-activating protein RanGAP1-dependent translocation of MYCBP2 to the nucleus Mus musculus 5634
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Organism

Organism UniProt Comment Textmining
Mus musculus Q7TPH6
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Source Tissue

Source Tissue Comment Organism Textmining
neuron
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 Mus musculus
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General Information

General Information Comment Organism
physiological function loss of E3 ubiquitin ligase MYCBP2 causes the up-regulation of small GTPase Ran and GTPase-activating protein RanGAP1 in dorsal root ganglia under basal conditions and during inflammatory hyperalgesia. SUMOylated RanGAP1 physically interacts with MYCBP2 and inhibits its E3 ubiquitin ligase activity. Stimulation of neurons induces a RanGAP1-dependent translocation of MYCBP2 to the nucleus. In the nucleus of in dorsal root ganglia neurons MYCBP2 co-localizes with Ran and facilitates through its RCC1-like domain the GDP/GTP exchange of Ran. The nuclear localization of Ran is strongly increased in MYCBP2-deficient dorsal root ganglia Mus musculus