Literature summary for 2.3.2.32 extracted from

Xu, J.; Li, L.; Yu, G.; Ying, W.; Gao, Q.; Zhang, W.; Li, X.; Ding, C.; Jiang, Y.; Wei, D.; Duan, S.; Lei, Q.; Li, P.; Shi, T.; Qian, X.; Qin, J.; Jia, L.
The neddylation-cullin 2-RBX1 E3 ligase axis targets tumor suppressor RhoB for degradation in liver cancer (2015), Mol. Cell. Proteomics, 14, 499-509 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin 2]-L-lysine	Homo sapiens	-	[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin 2]-N6-[NEDD8-protein]-yl-L-lysine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-
Hep-G2 cell	-	Homo sapiens	-
Huh-7 cell	-	Homo sapiens	-
MCF-7 cell	-	Homo sapiens	-
MiaPaCa-2 cell	-	Homo sapiens	-
umbilical vein endothelial cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin 2]-L-lysine	-	Homo sapiens	[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin 2]-N6-[NEDD8-protein]-yl-L-lysine	-	?

Synonyms

Synonyms	Comment	Organism
cullin 2-RBX1 E3 ligase	-	Homo sapiens
RBX1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	down-regulation of RBX1 significantly induces RhoB accumulation and blocks tumor suppressor RhoB degradation in the presence of cycloheximide	Homo sapiens

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Release 2023.1 (January 2023)