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Literature summary for 2.3.2.32 extracted from

  • Huang, G.; Kaufman, A.; Ramanathan, Y.; Singh, B.
    SCCRO (DCUN1D1) promotes nuclear translocation and assembly of the neddylation E3 complex (2011), J. Biol. Chem., 286, 10297-10304 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.32

Cloned(Commentary)

Cloned (Comment) Organism
expressed in MEF cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin 1]-L-lysine Homo sapiens
-
 [E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin 1]-N6-[NEDD8-protein]-yl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin 1]-L-lysine
-
 Homo sapiens [E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin 1]-N6-[NEDD8-protein]-yl-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
Dcn1
-
 Homo sapiens
DCUN1D1
-
 Homo sapiens
SCCRO
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism in the nucleus, SCCRO enhances recruitment of Ubc12 to cullin 1 to promote neddylation. The enzyme facilitates the subcellular localization of neddylation components, which is required for cullin neddylation in vivo Homo sapiens
physiological function the enzyme enhances cell proliferation by promoting cullin neddylation Homo sapiens