Literature summary for 2.3.2.32 extracted from

Kim, A.; Bommelje, C.; Lee, B.; Yonekawa, Y.; Choi, L.; Morris, L.; Huang, G.; Kaufman, A.; Ryan, R.; Hao, B.; Ramanathan, Y.; Singh, B.
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation (2008), J. Biol. Chem., 283, 33211-33220 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin 1]-L-lysine	Mus musculus	-	[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin 1]-N6-[NEDD8-protein]-yl-L-lysine	-	?
[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin 3]-L-lysine	Mus musculus	-	[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin 3]-N6-[NEDD8-protein]-yl-L-lysine	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin 1]-L-lysine	-	Mus musculus	[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin 1]-N6-[NEDD8-protein]-yl-L-lysine	-	?
[E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine + [cullin 3]-L-lysine	-	Mus musculus	[E2 NEDD8-conjugating enzyme]-L-cysteine + [cullin 3]-N6-[NEDD8-protein]-yl-L-lysine	-	?

Synonyms

Synonyms	Comment	Organism
DCUN1D1	-	Mus musculus
SCCRO	-	Mus musculus

General Information

General Information	Comment	Organism
metabolism	the enzyme is an important component of the neddylation E3 complex that functions to recruit charged E2 and is involved in the release of inhibitory effects of CAND1 on cullin-RING ligase E3 complex assembly and activity. The enzyme binds to the components of the neddylation pathway (cullin-ROC1, Ubc12, and CAND1) and augments but is not required for cullin neddylation	Mus musculus

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Release 2023.1 (January 2023)