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Literature summary for 2.3.2.31 extracted from
- Structural studies of HHARI/UbcH7-Ub reveal unique E2-Ub conformational restriction by RBR RING1 (2017), Structure, 25, 890-900 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| structure of ARIH1 in complex with UbcH7-ubiquitin, to 3.2 A resolution. ARIH1 is autoinhibited even in the complex. The ARIH1 UBA-L domain binds to ubiquitin and NEDD8 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9Y4X5 | - |
- |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | a short extension of ARIH1 RING1, Zn2+-loop II, acts as a steric wedge to disrupt closed E2-ubiquitin, resulting in open E2-ubiquitin that favors ubiquitin transfer to the E3 active site | Homo sapiens |
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Release 2023.1 (January 2023)
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