Literature summary for 2.3.2.31 extracted from

Di Rita, A.; Maiorino, T.; Bruqi, K.; Volpicelli, F.; Bellenchi, G.C.; Strappazzon, F.
miR-218 inhibits mitochondrial clearance by targeting PRKN E3 ubiquitin ligase (2020), Int. J. Mol. Sci., 21, 355 .

Search for more literature for 2.3.2.31

Cloned(Commentary)

Cloned (Comment)	Organism
expression in HEK-293 cell	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	mitophagy is regulated by a positive ubiquitylation feedback loop in which the PINK1 kinase phosphorylates both ubiquitin and the E3 ubiquitin ligase parkin. This event recruits parkin to the mitochondria	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O60260	isoform parkin	-

Synonyms

Synonyms	Comment	Organism
parkin RBR E3 ubiquitin ligase	-	Homo sapiens
PRKN	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	miR-218 targets parkin and negatively regulates PINK1/parkin-mediated mitophagy. Overexpression of microRNA miR-218 reduces parkin mRNA levels, reducing protein content and deregulating the E3 ubiquitin ligase action. Following miR-218 overexpression, mitochondria result less ubiquitylated and the autophagy machinery fails to proceed with correct mitochondrial clearance	Homo sapiens

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Release 2023.1 (January 2023)