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Literature summary for 2.3.2.31 extracted from

  • Wenzel, D.; Lissounov, A.; Brzovic, P.; Klevit, R.
    UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids (2011), Nature, 474, 105-108 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.31

Protein Variants

Protein Variants Comment Organism
C357A the mutant shows wild type activity Homo sapiens
I188A inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[E2 ubiquitin-conjugating enzyme UbcH5]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine Homo sapiens overall reaction [E2 ubiquitin-conjugating enzyme UbcH5]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
-
 ?
[E2 ubiquitin-conjugating enzyme UBCH7]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine Homo sapiens overall reaction [E2 ubiquitin-conjugating enzyme UBCH7]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P0ABD5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[E2 ubiquitin-conjugating enzyme UbcH5]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine overall reaction Homo sapiens [E2 ubiquitin-conjugating enzyme UbcH5]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
-
 ?
[E2 ubiquitin-conjugating enzyme UBCH7]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine overall reaction Homo sapiens [E2 ubiquitin-conjugating enzyme UBCH7]-L-cysteine + [acceptor protein]-N6-ubiquitinyl-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
HHARI human homologue of ariadne Homo sapiens
Parkin
-
 Homo sapiens
RBR E3
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 Homo sapiens