Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysyl-tRNALys + phosphatidylglycerol | Mycobacterium avium | - |
tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol | - |
? | |
L-lysyl-tRNALys + phosphatidylglycerol | Mycobacterium avium 104 | - |
tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium avium | A0QHC4 | - |
- |
Mycobacterium avium 104 | A0QHC4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysyl-tRNALys + phosphatidylglycerol | - |
Mycobacterium avium | tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol | - |
? | |
L-lysyl-tRNALys + phosphatidylglycerol | - |
Mycobacterium avium 104 | tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LysX | - |
Mycobacterium avium |
General Information | Comment | Organism |
---|---|---|
malfunction | a Mycobacterium avium lysX mutant strain undergoes a transition in phenotype by switching the carbon metabolism to beta-oxidation of fatty acids, along with accumulation of lipid inclusions. Proteins associated with intracellular survival are upregulated in the lysX mutant, even during extracellular growth, preparing bacteria for the conditions occurring inside host cells. In line with this, the lysX mutant exhibits enhanced intracellular growth in human-blood-derived monocytes | Mycobacterium avium |
metabolism | significance of lysX in the metabolism and virulence of the environmental pathogen Mycobacterium avium hominissuis | Mycobacterium avium |
physiological function | lysyl-phosphatidylglycerol is one of the components of the mycobacterial membrane that contributes to the resistance to cationic antimicrobial peptides, a host-induced frontline defense against invading pathogens. Its production is catalyzed by LysX, a bifunctional protein with lysyl transferase and lysyl transfer RNA synthetase activity | Mycobacterium avium |