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Literature summary for 2.3.2.3 extracted from

  • Atila, M.; Katselis, G.; Chumala, P.; Luo, Y.
    Characterization of N-succinylation of L-lysylphosphatidylglycerol in Bacillus subtilis using tandem mass spectrometry (2016), J. Am. Soc. Mass Spectrom., 27, 1606-1613 .
    View publication on PubMed
Search for more literature for 2.3.2.3

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysyl-tRNALys + phosphatidylglycerol Bacillus subtilis
-
 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?
L-lysyl-tRNALys + phosphatidylglycerol Bacillus subtilis 168
-
 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis C0H3X7
-
-
Bacillus subtilis 168 C0H3X7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysyl-tRNALys + phosphatidylglycerol
-
 Bacillus subtilis tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?
L-lysyl-tRNALys + phosphatidylglycerol
-
 Bacillus subtilis 168 tRNALys + 3-O-L-lysyl-1-O-phosphatidylglycerol
-
 ?

Synonyms

Synonyms Comment Organism
lysyl-PG synthase
-
 Bacillus subtilis
MprF
-
 Bacillus subtilis
phosphatidylglycerol lysyltransferase UniProt Bacillus subtilis

General Information

General Information Comment Organism
additional information compound determination by mass spectrometry Bacillus subtilis
physiological function in comparison with Gram-negative bacteria, Gram-positive bacteria in general have much less zwitterionic phosphatidylethanolamine. They are known for producing aminoacylated phosphatidylglycerol (PG), especially positively charged L-lysyl-PG, which is catalyzed by lysyl-PG synthase MprF. Enzyme MprF appears to have a broad range of specificity for L-aminoacyl transfer RNAs. Lipids from Bacillus subtilis are extremely abundant in lysyl-PG and somewhat rich in alanyl-PG. It appears that N-succinylation of lipids in Bacillus subtilis strain 168 is specific to lysyl-PG but not alanyl-PG Bacillus subtilis