Literature summary for 2.3.2.27 extracted from

Ackermann, L.; Schell, M.; Pokrzywa, W.; Kevei, E.; Gartner, A.; Schumacher, B.; Hoppe, T.
E4 ligase-specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis (2016), Nat. Struct. Mol. Biol., 23, 995-1002 .

Search for more literature for 2.3.2.27

Organism

Organism	UniProt	Comment	Textmining
Caenorhabditis elegans	Q09349	isoform Ufd-2	-

Synonyms

Synonyms	Comment	Organism
UFD-2	-	Caenorhabditis elegans

General Information

General Information	Comment	Organism
physiological function	UFD-2 is a mediator of DNA-damage-induced apoptosis. After initiation of homologous recombination by RAD-51, UFD-2 forms foci that contain substrate-processivity factors including the ubiquitin-selective segregase CDC-48 (p97), the deubiquitination enzyme ATX-3 (Ataxin-3) and the proteasome. In the absence of UFD-2, RAD-51 foci persist, and DNA damage-induced apoptosis is prevented. UFD-2 foci are retained until recombination intermediates are removed by the Holliday-junction-processing enzymes GEN-1, MUS-81 or XPF-1. Formation of UFD-2 foci also requires proapoptotic CEP-1 (p53) signaling	Caenorhabditis elegans

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)