Literature summary for 2.3.2.27 extracted from

An, J.; Liu, X.; Song, L.; You, C.; Wang, X.; Hao, Y.
Apple RING finger E3 ubiquitin ligase MdMIEL1 negatively regulates salt and oxidative stresses tolerance (2017), J. Plant Biol., 60, 137-145 .

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Organism

Organism	UniProt	Comment	Textmining
Malus domestica	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [MYB1]-L-lysine	-	Malus domestica	[E2 ubiquitin-conjugating enzyme]-L-cysteine + [MYB1]-N6-ubiquitinyl-L-lysine	-	?

Synonyms

Synonyms	Comment	Organism
MIEL1	-	Malus domestica

General Information

General Information	Comment	Organism
physiological function	E3 ligase MIEL1 interacts with MYB1, regulator for anthocyanin accumulation. MIEL1 ubiquitinates MYB1 protein, followed by degradation through a 26S proteasome pathway. MIEL1 negatively regulates anthocyanin accumulation by modulating the degradation of MYB1 protein. Arabidopsis thaliana MIEL1 expression lines produce much less anthocyan than wild-type	Malus domestica

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Release 2023.1 (January 2023)