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Literature summary for 2.3.2.27 extracted from

  • Suisse, A.; Bekes, M.; Huang, T.T.; Treisman, J.E.
    The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity (2018), Fly, 12, 118-126 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
MLN4924 Nedd8 activating enzyme (NAE1) inhibitor, interferes with the activation of all cullin E3-ligases Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
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 Mus musculus
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myoblast primary myoblast cell Mus musculus
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primary cell
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 Mus musculus
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General Information

General Information Comment Organism
physiological function cullin E3-ligase activity is necessary for entry into the terminal myogenic differentiation program and myotube formation. Cullin inhibition prevents entry into the terminal myogenic differentiation program, and satellite cells treated with inhibitor MLN4924 fail to differentiate. Protein levels of myogenic repressors Bhlhe41 and Id1, but not that of ZBTB38, are mediated through the activity of cullin E3-ligases Mus musculus