Literature summary for 2.3.2.27 extracted from

Liu, H.; Stone, S.L.
Cytoplasmic degradation of the Arabidopsis transcription factor abscisic acid insensitive 5 is mediated by the RING-type E3 ligase KEEP ON GOING (2013), J. Biol. Chem., 288, 20267-20279.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	Q9FY48	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [ABI5]-L-lysine	ABI5 i.e. abscisic acid-responsive transcription factor	Arabidopsis thaliana	[E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[ABI5]-L-lysine	-	?

Synonyms

Synonyms	Comment	Organism
KEEP ON GOING	-	Arabidopsis thaliana
KEG	-	Arabidopsis thaliana

General Information

General Information	Comment	Organism
physiological function	RING-type E3 ligase KEG interacts directly with abscisic acid-responsive transcription factor ABI5 via its conserved C3 region. Interactions between KEG and ABI5 are observed in the cytoplasm and trans-Golgi network only when the RING domain of KEG is inactivated or when ABI5 is stabilized via mutations. Deletion of the C-terminal region of ABI5 or substituting lysine 344 for alanine prohibits protein turnover	Arabidopsis thaliana

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Release 2023.1 (January 2023)