Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NXI6 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-(ubiquitin)n-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [RNF186]-L-lysine | BNip1 is a Bcl-2 family protein | Homo sapiens | [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-(ubiquitin)n-[RNF186]-L-lysine | isoform RNF186 undergoes RING-dependent self-ubiquitination | ? | |
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [BNip1]-L-lysine | BNip1 is a Bcl-2 family protein | Homo sapiens | [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[BNip1]-L-lysine | BNip1 is polyubiquitinated by isoform RNF186 through K29 and K63 linkage in vivo. This modification promotes BNip1 transportation to mitochondria but has no influence on its protein level | ? |
Synonyms | Comment | Organism |
---|---|---|
Ring finger protein 186 | - |
Homo sapiens |
RNF186 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | RING finger E3 ligase RNF186 participates in the process of endoplasmic reticulum stress-mediated apoptosis. Overexpression of RNF186 stimulates upregulation of endoplasmic reticulum sensor proteins and rapid transmission of endoplasmic reticulum Ca2+ in Hela cells, while RNF186 knockdown leads to a moderate degree of resistance to endoplasmic reticulum stress. The half-life of substrate RNF186 is prolonged under endoplasmic reticulum stress, and the ubiquitination of BNip1 is greatly enhanced when endoplasmic reticulum stress occurs. Knockdown of BNip1 attenuates the stress signals at endoplasmic reticulum induced by RNF186 | Homo sapiens |