Literature summary for 2.3.2.27 extracted from

Raheja, R.; Liu, Y.; Hukkelhoven, E.; Yeh, N.; Koff, A.
The ability of TRIM3 to induce growth arrest depends on RING-dependent E3 ligase activity (2014), Biochem. J., 458, 537-545.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-ubiquitinyl-[UbcH5a]-L-cysteine + [p21]-L-lysine	substrate p21 is a protein necessary for the proliferation of a subset of platelet-derived growth factor-transformed proneural glioma cells	Mus musculus	[UbcH5a]-L-cysteine + N6-ubiquitinyl-[p21]-L-lysine	UbcH5a is a preferred E2 enzyme for TRIM3-dependent p21 ubiquitination. Ubiquitination is practically eliminated in a p21 K15R/K74R/K91R/K136R quadruple mutant	?

Synonyms

Synonyms	Comment	Organism
TRIM3	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	the RING domain is necessary for TRIM3-induced growth arrest of cells	Mus musculus

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Release 2023.1 (January 2023)