Literature summary for 2.3.2.27 extracted from

Xu, Z.; Kohli, E.; Devlin, K.I.; Bold, M.; Nix, J.C.; Misra, S.
Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes (2008), BMC Struct. Biol., 8, 26.

Cloned(Commentary)

Cloned (Comment)	Organism
-	Danio rerio

Crystallization (Commentary)

Crystallization (Comment)	Organism
2.9 A crystal structure of the ubiquitin ligase CHIP U-box domain complexed with UbcH5a. CHIP binds to UbcH5 and Ubc13 through similar specificity determinants located on the long loops and central helix of the CHIP U-box, and on the N-terminal helix and loops L4 and L7 of its cognate E2 enzymes including a key S-P-A motif. The determinants make different relative contributions to the overall interactions between CHIP and the two E2 enzymes. CHIP undergoes auto-ubiquitination by UbcH5 but not by Ubc13-Uev1a. Instead, CHIP drives the formation of unanchored polyubiquitin by Ubc13-Uev1a. CHIP also interacts productively with the class III E2 enzyme Ube2e2	Danio rerio

Crystallization (Comment)

Organism

2.9 A crystal structure of the ubiquitin ligase CHIP U-box domain complexed with UbcH5a. CHIP binds to UbcH5 and Ubc13 through similar specificity determinants located on the long loops and central helix of the CHIP U-box, and on the N-terminal helix and loops L4 and L7 of its cognate E2 enzymes including a key S-P-A motif. The determinants make different relative contributions to the overall interactions between CHIP and the two E2 enzymes. CHIP undergoes auto-ubiquitination by UbcH5 but not by Ubc13-Uev1a. Instead, CHIP drives the formation of unanchored polyubiquitin by Ubc13-Uev1a. CHIP also interacts productively with the class III E2 enzyme Ube2e2

Danio rerio

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	Q7ZTZ6	isoform CHIP	-

Synonyms

Synonyms	Comment	Organism
CHIP	-	Danio rerio
STIP1 homology and U-Box containing protein 1	-	Danio rerio

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Release 2023.1 (January 2023)