Literature summary for 2.3.2.26 extracted from

Nakatsukasa, K.; Sone, M.; Alemayehu, D.; Okumura, F.; Kamura, T.
The HECT-type ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the FEAR network, in G2/M phase (2018), FEBS Lett., 592, 1716-1724 .

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Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	Q03280	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [Spo12]-L-lysine	-	Saccharomyces cerevisiae	[E2 ubiquitin-conjugating enzyme]-L-cysteine + [Spo12]-N6-ubiquitinyl-L-lysine	-	-

Synonyms

Synonyms	Comment	Organism
E3 ubiquitin-protein ligase TOM1	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	ubiquitin ligase Tom1 contributes to the turnover of Spo12, a component of the Cdc14 early anaphase release network, in G2/M phase. Tom1 and Spo12 interact. Overexpression of Spo12 is cytotoxic in the absence of Tom1. In S phase, Spo12 is degraded even in the absence of Tom1 and Cdh1	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)