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Literature summary for 2.3.2.26 extracted from

  • Dong, S.; Liu, J.; Li, L.; Wang, H.; Ma, H.; Zhao, Y.; Zhao, J.
    The HECT ubiquitin E3 ligase Smurf2 degrades my-opioid receptor 1 in the ubiquitin-proteasome system in lung epithelial cells (2019), Am. J. Physiol. Cell Physiol., 316, C632-C640 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus A2A5Z6
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Source Tissue

Source Tissue Comment Organism Textmining
epithelium
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Mus musculus
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lung
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [my-opioid receptor MOR1]-L-lysine
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Mus musculus [E2 ubiquitin-conjugating enzyme]-L-cysteine + [my-opioid receptor MOR1]-N6-ubiquitinyl-L-lysine
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Synonyms

Synonyms Comment Organism
Smurf2
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Mus musculus

General Information

General Information Comment Organism
physiological function Smurf2 mediates [D-Ala2,NMePhe4,Gly5-ol]-enkephalin (DAMGO, an agonist of MOR1)-induced MOR1 ubiquitination and degradation. DAMGO decreases MOR1 levels in the ubiquitin-proteasome system. MOR1 is modified by a Lys48-linked polyubiquitin chain. Overexpression of Smurf2 induces MOR1 ubiquitination and accelerates DAMGO-induced MOR1 degradation, whereas downregulation of Smurf2 attenuates MOR1 degradation. DAMGO increases lung epithelial cell migration and proliferation, and the effect is attenuated by overexpressing Smurf2 Mus musculus