Literature summary for 2.3.2.25 extracted from

Tatham, M.H.; Plechanovova, A.; Jaffray, E.G.; Salmen, H.; Hay, R.T.
Ube2W conjugates ubiquitin to alpha-amino groups of protein N-termini (2013), Biochem. J., 453, 137-145.

Search for more literature for 2.3.2.25

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96B02	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [SUMO-2]-N-terminal-amino acid	-	Homo sapiens	[E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[SUMO-2]	N-terminal mono-ubiquitylation of SUMO-2 primes it for poly-ubiquitylation by the Ubc13-UEV1 (ubiquitin-conjugating enzyme E2 variant 1) heterodimer	?
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [Ube2W]-N-terminal-amino acid	-	Homo sapiens	[E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[Ube2W]	isoform Ube2W ubiquitylates its own N-terminus	?

Synonyms

Synonyms	Comment	Organism
Ubc16	-	Homo sapiens
UBE2W	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	Ube2W is an E2 ubiquitin-conjugating enzyme with specific protein N-terminal monoubiquitylation activity. Ube2W conjugates ubiquitin to its own N-terminus, but also to that of the small ubiquitin-like modifier SUMO in a manner dependent on the SUMO-targeted ubiquitin ligase RNF4, i.e.RING finger protein 4	Homo sapiens

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Release 2023.1 (January 2023)