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Literature summary for 2.3.2.23 extracted from

  • Yu, H.; Xiang, P.; Pan, Q.; Huang, Y.; Xie, N.; Zhu, W.
    Ubiquitin-conjugating enzyme E2T is an independent prognostic factor and promotes gastric cancer progression (2016), Tumour Biol., 37, 11723-11732 .
    View publication on PubMed
Search for more literature for 2.3.2.23

Application

Application Comment Organism
diagnostics ubiquitin-conjugating enzyme E2T is an independent prognostic factor and promotes gastric cancer progression Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
gene UBE2T, located in chromosome 1q32.1, quantitative real-time PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information knockdown of enzyme UBE2T by specific siRNA in BGC-823 cells and HTB-103 cells can induce G1/S phase arrest in gastric cancer cells, which in turn contributes to the stimulating growth properties of gastric cancer cells. Overexpression of UBE2T in AGS cells and CRL-5974 cells. Phenotypes, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine Homo sapiens
-
 [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NPD8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
 Homo sapiens
-
BGC-823 cell
-
 Homo sapiens
-
gastric cancer cell quantitative real-time PCR enzyme expression analysis in gastric cancer cell lines, overview Homo sapiens
-
HGC-27 cell
-
 Homo sapiens
-
KATO-III cell
-
 Homo sapiens
-
MGC-803 cell
-
 Homo sapiens
-
MKN-45 cell
-
 Homo sapiens
-
SGC-7901 cell
-
 Homo sapiens
-
SNU-1 cell
-
 Homo sapiens
-
SNU-16 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 Homo sapiens [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
UBE2T
-
 Homo sapiens
ubiquitin-conjugating enzyme E2T
-
 Homo sapiens

General Information

General Information Comment Organism
evolution ubiquitin-conjugating enzyme E2T (UBE2T) is a member of the E2 family that mediates the ubiquitin-proteasome system and regulates gene expression Homo sapiens
malfunction UBE2T downregulation induces gastric cancer cell cycle arrest Homo sapiens
physiological function enzyme UBE2T promotes cell proliferation and inhibits cell cycle arrest. In addition, UBE2T modulates cell mobility by inducing epithelial-mesenchymal transition. UBE2T plays an important role in the tumorigenesis of gastric cancer, it promotes tumor cell growth and metastasis. UBE2T has been reported to be recruited independently to regulate FANCD2 monoubiquitination and participates in the Fanconi anemia pathway together with FANCD2 Homo sapiens