Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.23 extracted from

  • Fiesel, F.; Moussaud-Lamodiere, E.; Ando, M.; Springer, W.
    A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently (2014), J. Cell Sci., 127, 3488-3504.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.23

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine Homo sapiens
-
 [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 Homo sapiens [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
-
 ?

Synonyms

Synonyms Comment Organism
E2 ubiquitin conjugating enzyme
-
 Homo sapiens
UBE2D
-
 Homo sapiens
UBE2L3
-
 Homo sapiens
UBE2N
-
 Homo sapiens
UBE2R1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of E2 enzymes delays ubiquitylation and degradation of mitochondrial substrates like p62 and the adaptor protein p62/SQSTM1. Depletion of UBE2R1 enhances the translocation of Parkin to, and clustering of, mitochondria Homo sapiens
physiological function the cognate E2 coenzymes of E3 enzyme Parkin regulate the activation, translocation and enzymatic functions of Parkin during mitochondrial quality control. UBE2D family members and UBE2L3 redundantly charge the RING-HECT hybrid ligase Parkin with ubiquitin, resulting in its initial activation and translocation to mitochondria. UBE2N primarily mediates the proper clustering of mitochondria, a prerequisite for degradation. Depletion of UBE2R1 results in enhanced Parkin translocation and clustering upon mitochondrial uncoupling Homo sapiens
physiological function E2 enzymes regulate activation and mitochondrial translocation of Parkin. UBE2L3 is able to charge Parkin with ubiquitin and are essential for its initial activation Homo sapiens