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Literature summary for extracted from

  • van Wijk, S.J.; Timmers, H.T.
    The family of ubiquitin-conjugating enzymes (E2s):deciding between life and death of proteins (2010), FASEB J., 24, 981-93.
    View publication on PubMed


Localization Comment Organism GeneOntology No. Textmining
additional information many E2 enzymes are found both in the nucleus and in the cytoplasm. Some E2 enzymes are exclusively restructed to specific compartments Homo sapiens


Organism UniProt Comment Textmining
Homo sapiens
35 active E2 enzymes have been identified

Source Tissue

Source Tissue Comment Organism Textmining
additional information most E2 enzymes have been identified in a wide variety of tissues and cell types Homo sapiens


Synonyms Comment Organism
E2 enzyme
Homo sapiens
ubiquitin-conjugating enzyme (E2)
Homo sapiens


Organism Comment Expression
Homo sapiens the majority of E2s are expressed ubiquitously additional information

General Information

General Information Comment Organism
physiological function Some E2s possess N and/or C-terminal extensions that mediate E2-specific processes: class I, enzyme consists of the catalytic domain, without extensions, Class II, enzyme has a N-terminal extension, class III, enzyme has a C-terminal extension, class IV, enzyme has both, N- and C-terminal extensions, showing differences in function, subcellular localization, stabilization of the interaction with E1 enzymes, or modulation of the activity of the interacting E3 Homo sapiens
physiological function the family of ubiquitin-conjugating enzymes is characterized by the presence of a highly conserved ubiquitin-conjugating (UBC) domain Homo sapiens