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Literature summary for extracted from

  • Xu, Z.; Kohli, E.; Devlin, K.I.; Bold, M.; Nix, J.C.; Misra, S.
    Interactions between the quality control ubiquitin ligase CHIP and ubiquitin conjugating enzymes (2008), BMC Struct. Biol., 8, 26.
    View publication on PubMedView publication on EuropePMC


Cloned (Comment) Organism
Danio rerio

Crystallization (Commentary)

Crystallization (Comment) Organism
2.9 A crystal structure of the ubiquitin ligase CHIP U-box domain complexed with UbcH5a. CHIP binds to UbcH5 and Ubc13 through similar specificity determinants located on the long loops and central helix of the CHIP U-box, and on the N-terminal helix and loops L4 and L7 of its cognate E2 enzymes including a key S-P-A motif. The determinants make different relative contributions to the overall interactions between CHIP and the two E2 enzymes. CHIP undergoes auto-ubiquitination by UbcH5 Danio rerio


Organism UniProt Comment Textmining
Danio rerio Q6PC58


Synonyms Comment Organism
Danio rerio
Danio rerio