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Literature summary for extracted from

  • Pelzer, C.; Kassner, I.; Matentzoglu, K.; Singh, R.K.; Wollscheid, H.P.; Scheffner, M.; Schmidtke, G.; Groettrup, M.
    UBE1L2, a novel E1 enzyme specific for ubiquitin (2007), J. Biol. Chem., 282, 23010-23014.
    View publication on PubMed


Organism UniProt Comment Textmining
Homo sapiens P62837

Source Tissue

Source Tissue Comment Organism Textmining
SW-60 cell colon carcinoma cell Homo sapiens
testis most abundant expression Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[ubiquitin-activating protein Uba6]-S-ubiquitinyl-L-cysteine + [ubiquitin carrier protein UbcH5B]-L-cysteine
Homo sapiens [ubiquitin-activating protein Uba]-L-cysteine + [ubiquitin carrier protein UbcH5B]-S-ubiquitinyl-L-cysteine recombinant E1 enzyme Uba6 can activate ubiquitin and transfer it onto the ubiquitin-conjugating enzyme UbcH5B. Ubiquitin activated by Uba6 can be used for ubiquitylation of p53 and supports the autoubiquitylation of the E3 ubiquitin ligases HectH9 and E6-AP ?


Synonyms Comment Organism
Homo sapiens
Homo sapiens