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Literature summary for 2.3.2.22 extracted from

  • Randazzo, P.; Aubert-Frambourg, A.; Guillot, A.; Auger, S.
    The MarR-like protein PchR (YvmB) regulates expression of genes involved in pulcherriminic acid biosynthesis and in the initiation of sporulation in Bacillus subtilis (2016), BMC Microbiol., 16, 190 .
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
gene yvmC is organized in the yvmC-cypX operon, genetic organization and expression analysis Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-leucyl-tRNALeu Bacillus subtilis
-
 2 tRNALeu + cyclo(L-leucyl-L-leucyl)
-
 ?
2 L-leucyl-tRNALeu Bacillus subtilis 168
-
 2 tRNALeu + cyclo(L-leucyl-L-leucyl)
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis O34351
-
-
Bacillus subtilis 168 O34351
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-leucyl-tRNALeu
-
 Bacillus subtilis 2 tRNALeu + cyclo(L-leucyl-L-leucyl)
-
 ?
2 L-leucyl-tRNALeu
-
 Bacillus subtilis 168 2 tRNALeu + cyclo(L-leucyl-L-leucyl)
-
 ?

Synonyms

Synonyms Comment Organism
cyclodipeptide synthase
-
 Bacillus subtilis
YvmC
-
 Bacillus subtilis

General Information

General Information Comment Organism
metabolism in Bacillus subtilis, the enzymes YvmC and CypX are involved in pulcherriminic acid biosynthesis. The cyclodipeptide synthase YvmC utilizes charged leucyl-tRNAs as substrate to catalyze the formation of cyclo-L-leucyl-L-leucyl (cLL). The cytochrome P450 CypX is implicated in the transformation of cLL into pulcherriminic acid. Pulcherriminic acid derived from cyclo-L-leucyl-L-leucyl is excreted and chelates free ferric ions to form the pulcherrimin. Analysis of mechanisms controlling the transcription of the yvmC-cypX operon, overview. The Bacillus subtilis YvmB MarR-like regulator is the major transcription factor controlling yvmC-cypX expression, involvement of YvmB as repressor in the control of yvm-CcypX expression. Expression of yvmB depends on iron availability. Genes yvmBA, yvmC-cypX and yvnB are identified for negative regulation and yisI for positive regulation. A 14-bp palindromic motif constitutes the YvmB binding site. YvmB might not control expression of yisI, whose encoding protein plays a negative role in the regulation of the sporulation initiation pathway. YvmB appears as an additional regulatory element into the cell's decision to grow or sporulate Bacillus subtilis