Literature summary for 2.3.2.20 extracted from

Jacques, I.; Moutiez, M.; Witwinowski, J.; Darbon, E.; Martel, C.; Seguin, J.; Favry, E.; Thai, R.; Lecoq, A.; Dubois, S.; Pernodet, J.; Gondry, M.; Belin, P.
Analysis of 51 cyclodipeptide synthases reveals the basis for substrate specificity (2015), Nat. Chem. Biol., 11, 721-727.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe	Streptomyces albulus	highest activity	tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)	-	?
L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe	Bacillus sp. NSP9.1	second best activity	tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)	-	?
L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe	Bacillus sp. 171095_106	second best activity	tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)	-	?
L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet	Streptomyces albulus	lowest activity	tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)	-	?
L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet	Bacillus sp. NSP9.1	lowest activity	tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)	-	?
L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet	Bacillus sp. 171095_106	lowest activity	tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)	-	?
L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe	Bacillus sp. NSP9.1	highest activity	2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)	-	?
L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe	Bacillus sp. 171095_106	highest activity	2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)	-	?
L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe	Streptomyces albulus	second best activity	2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)	-	?
L-phenylalanyl-tRNAPhe + L-tyrosinyl-tRNATyr	Streptomyces albulus	-	tRNAPhe + tRNATyr + cyclo(L-phenylalanyl-L-tyrosinyl)	-	?

Organism

Organism	UniProt	Comment	Textmining
Bacillus sp. 171095_106	-	-	-
Bacillus sp. NSP9.1	-	-	-
Streptomyces albulus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe	highest activity	Streptomyces albulus	tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)	-	?
L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe	second best activity	Bacillus sp. NSP9.1	tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)	-	?
L-leucyl-tRNALeu + L-phenylalanyl-tRNAPhe	second best activity	Bacillus sp. 171095_106	tRNALeu + tRNAPhe + cyclo(L-leucyl-L-phenylalanyl)	-	?
L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet	lowest activity	Streptomyces albulus	tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)	-	?
L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet	lowest activity	Bacillus sp. NSP9.1	tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)	-	?
L-phenylalanyl-tRNAPhe + L-methionyl-tRNAMet	lowest activity	Bacillus sp. 171095_106	tRNAPhe + tRNAMet + cyclo(L-phenylalanyl-L-methionyl)	-	?
L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe	highest activity	Bacillus sp. NSP9.1	2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)	-	?
L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe	highest activity	Bacillus sp. 171095_106	2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)	-	?
L-phenylalanyl-tRNAPhe + L-phenylalanyl-tRNAPhe	second best activity	Streptomyces albulus	2 tRNAPhe + cyclo(L-phenylalanyl-L-phenylalanyl)	-	?
L-phenylalanyl-tRNAPhe + L-tyrosinyl-tRNATyr	-	Streptomyces albulus	tRNAPhe + tRNATyr + cyclo(L-phenylalanyl-L-tyrosinyl)	-	?

Synonyms

Synonyms	Comment	Organism
CDPS	-	Streptomyces albulus
CDPS	-	Bacillus sp. NSP9.1
CDPS	-	Bacillus sp. 171095_106
cyclodipeptide synthase	-	Streptomyces albulus
cyclodipeptide synthase	-	Bacillus sp. NSP9.1
cyclodipeptide synthase	-	Bacillus sp. 171095_106

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Release 2023.1 (January 2023)